雪旺细胞促进周围神经再生机制的研究进展

doi:10.16352/j.issn.1001-6325.2022.01.020

基础医学与临床 ›› 2022, Vol. 42 ›› Issue (1): 145-148.doi: 10.16352/j.issn.1001-6325.2022.01.020

雪旺细胞促进周围神经再生机制的研究进展

杨溢铎, 国海东, 邵水金^*, 刘玉璞

上海中医药大学基础医学院人体解剖学教研室,上海 201203

收稿日期:2020-11-27 修回日期:2021-05-06 出版日期:2022-01-05 发布日期:2022-01-05
通讯作者: ^* shaoshuijin@163.com
基金资助:
国家自然科学基金(8187150017)

Research progress on mechanism of Schwann cells promoting peripheral nerve regeneration

YANG Yi-duo, GUO Hai-dong, SHAO Shui-jin^*, LIU Yu-pu

Department of Human Anatomy,School of Basic Medicine,Shanghai University of Traditional Chinese Medicine, Shanghai 201203,China

Received:2020-11-27 Revised:2021-05-06 Online:2022-01-05 Published:2022-01-05
Contact: ^* shaoshuijin@163.com

摘要/Abstract

摘要： 雪旺细胞(SCs)具有强大的可塑性。周围神经损伤后,雪旺细胞去分化为修复表型,主导了修复过程。c-Jun氨基末端激酶、有丝分裂原激活的蛋白激酶(MAPK)等多种信号通路和转录调节因子参与调控雪旺细胞介导的修复程序。本综述讨论了雪旺细胞促进周围神经再生的主要信号通路与转录调节因子。

关键词: 周围神经, 雪旺细胞, 信号通路, 神经再生, 修复机制

Abstract: Schwann cells (SCs) have a strong plasticity. After peripheral nerve injury, Schwann cells dedifferentiate into repair phenotype and dominate the repair process. C-Jun N-terminal kinase, mitogen activated protein kinase(MAPK) and other signaling pathways and transcriptional regulators are involved in regulating Schwann cell-mediated repair process. This review discusses the main signaling pathways and transcriptional regulators of Schwann cell promoting peripheral nerve regeneration.

Key words: peripheral nerve, Schwann cells, signal pathway, nerve regeneration, repair mechanism

中图分类号:

杨溢铎, 国海东, 邵水金, 刘玉璞. 雪旺细胞促进周围神经再生机制的研究进展[J]. 基础医学与临床, 2022, 42(1): 145-148.

YANG Yi-duo, GUO Hai-dong, SHAO Shui-jin, LIU Yu-pu. Research progress on mechanism of Schwann cells promoting peripheral nerve regeneration[J]. Basic & Clinical Medicine, 2022, 42(1): 145-148.

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雪旺细胞促进周围神经再生机制的研究进展

Research progress on mechanism of Schwann cells promoting peripheral nerve regeneration

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