关键词: 脊髓损伤, 外泌体, 多潜能间充质干细胞, siRNA

Abstract: Exosomes are membrane vesicles that are secreted by cells into the extracellular environment. Exosomes are a new strategy for the treatment of spinal cord injury. Exosomes are secreted by mesenchymal stem cells have anti-apoptotic, anti-inflammatory and pro-angiogenic effects in the treatment of spinal cord injury, which play a key role in nerve cell-cell communication and can delivery exogenous genetic material. Exosomes can cross the blood-brain barrier and are more stable than their parent cells, reducing the safety risks in the administration of viable cells.

Key words: spinal cord injury, exosomes, MSCs, siRNA