基础医学与临床 ›› 2018, Vol. 38 ›› Issue (5): 713-716.

• 短篇综述 • 上一篇    下一篇

幽门螺杆菌致病因子作用机制研究概述

毕月1,罗微2,谷海瀛1   

  1. 1. 宁波大学
    2. 天津医科大学总医院
  • 收稿日期:2017-09-18 修回日期:2017-12-25 出版日期:2018-05-05 发布日期:2018-04-28
  • 通讯作者: 谷海瀛 E-mail:clinmicrobiollab@vip.sina.com
  • 基金资助:
    浙江省自然科学基金;天津医科大学总医院青年孵育基金

An overview of mechanism research on Helicobacter pylori pathogenic factors

1,Wei LUO2,Gu Haiying   

  • Received:2017-09-18 Revised:2017-12-25 Online:2018-05-05 Published:2018-04-28
  • Contact: Gu Haiying E-mail:clinmicrobiollab@vip.sina.com

摘要: 幽门螺杆菌(Hp)与胃癌、胃炎和胃溃疡等胃肠道相关性疾病密切相关,但其详尽致病机制尚不清楚。既往的研究常集中在CagA(细胞毒素相关蛋白)、VacA(空泡毒素A)、Urease(脲酶)和DupA(十二指肠溃疡启动蛋白)等毒力因子上,但这些对于致病机制的揭示仍存在不足。近年来的研究揭示了既往致病因子的新进展,同时发现鞭毛、黏附素相关蛋白及溶血素等在致病机制中也扮演着重要角色。

关键词: 幽门螺杆菌, 毒力因子, 致病机制

Abstract: Helicobacter pylori is considered to be closely associated with gastritis, peptic ulcer, gastric cancer and other gastrointestinal diseases, but the detail of the pathogenesis is still unclear. The past researches often focused on virulence factors such as CagA (Cytotoxin-associated gene A), VacA (vacuolating cytotoxin A), Urease and DupA (duodenal ulcer-promoting gene), but these are not enough to reveal the pathogenic mechanism. Recent studies have not only revealed some new progresses of these past virulence factors but also indicated that Hp flagllum, adhesion protein and hemolysin play important roles in the pathogenic mechanism.

Key words: Helicobacter pylori, Virulence factor, Pathogenesis

中图分类号: