关键词: 肾素-血管紧张素系统, ACE/AngII/AT1轴, ACE2/Ang(1-7)/Mas轴, 脂肪组织, 糖脂代谢

Abstract: The renin angiotensin system includes two counterbalance axes: the ACE/AngII/AT1 axis and the ACE2/Ang(1-7)/Mas axis. The RAS can regulate glucose and lipid metabolism in adipose tissue. Most of evidences demonstrated that the ACE/AngII/AT1 axis can induce glucose metabolism disorders in adipose tissue，on the contrary, the ACE2/Ang(1-7)/Mas axis improves glucose metabolism. The RAS , which is over activated in obese patient, has been considered to be a potential link between obesity, dyslipidemia and insulin resistance. The effect of ACE/AngII/AT1 axis and ACE2/Ang(1-7)/Mas axis on lipid and glucose metabolism in adipose tissue should be futher investigated, and we may find a new target for improving glucose and lipid metabolism.

Key words: renin-angiotension system (RAS), ACE/AngII/AT1 axis, ACE2/Ang(1-7)/Mas axis, adipose tissue, glucose and lipid metabolism