基础医学与临床 ›› 2018, Vol. 38 ›› Issue (5): 703-707.

• 短篇综述 • 上一篇    下一篇

Wnt3a与Wnt5a信号途径转换对造血干细胞衰老的影响

李双1,孙倩倩1,余丽梅2,赵春华3   

  1. 1. 遵义医学院
    2. 贵州省细胞工程重点实验室
    3. 中国医学科学院基础医学研究所
  • 收稿日期:2017-12-21 修回日期:2018-03-20 出版日期:2018-05-05 发布日期:2018-04-28
  • 通讯作者: 赵春华 E-mail:18310100813@163.com
  • 基金资助:
    人参皂苷Rg1调节钙敏感受体影响异基因脐带血造血干细胞移植效果的机制探讨

Effects of Wnt3a and Wnt5a signaling pathway switching on hematopoietic stem cells senescence

  • Received:2017-12-21 Revised:2018-03-20 Online:2018-05-05 Published:2018-04-28

摘要: 造血干细胞(HSCs)衰老是机体造血免疫功能衰老的重要原因,在衰老相关疾病的发生中起着关键作用。一定条件下,经典Wnt3a/β-catenin的激活,明显有利于保持HSCs的极性与年轻态、自我更新与增殖、分化能力;非经典Wnt5a信号通路的激活,则可通过进一步激活细胞内Cdc42蛋白活化等,促发HSCs衰老,并间接抑制Wnt3a/β-catenin通路。对Wnt3a向Wnt5a信号通路转换及其干预的研究,不但阐释了HSCs衰老发生的机制,更明确了如何延缓衰老,提供了解决衰老相关疾病及保持年轻态的新策略。

关键词: 造血干细胞, 衰老, Wnt3a, Wnt5a

Abstract: Hematopoietic stem cells (HSCs) senescence is an important reason of hematopoietical and immunological function senescence. It also is play a key role during aging-related diseases development. Under certain conditions, the activation of classical Wnt3a/β-catenin is in favour of maintains polarity and young states of HSCs, self-renewing, proliferation and differentiation potency. Switching to the non-classical Wnt5a pathway, further activation of Cdc42 protein and others can promote HSCs ageing, and indirectly inhibits Wnt3a/beta-catenin pathway. The intervention of two Wnt signaling pathways switching and mechanism, not only can illustrate the mechanism of HSCs aging, but also clear how to slow down ageing. This could provide a new strategy on the solution of age-related diseases and keeping a young state.

Key words: hematopoietic stem cells, senescence, Wnt3a, Wnt5a