基础医学与临床 ›› 2016, Vol. 36 ›› Issue (11): 1596-1602.

• 短篇综述 • 上一篇    下一篇

PI3K/Akt在多囊卵巢综合征发病机制中作用的研究进展

李甜甜,张江宇,李荔   

  1. 广东省妇幼保健院
  • 收稿日期:2015-11-30 修回日期:2016-03-30 出版日期:2016-11-05 发布日期:2016-10-24
  • 通讯作者: 李荔 E-mail:lili-1406@163.com
  • 基金资助:
    广东省自然基因管理委员会;广东省科技厅;广东省人口和计划生育委员会;广东省中药局

PI3K/Akt signal pathway in pathogenesis of polycystic ovary syndrome

  • Received:2015-11-30 Revised:2016-03-30 Online:2016-11-05 Published:2016-10-24

摘要: 多囊卵巢综合征(PCOS)是一种生殖功能障碍合并代谢障碍的内分泌疾病,其病因及发病机制尚未明确。磷酯酰肌醇-3激酶/蛋白激酶B(PI3K/Akt)信号通路中的信号分子及蛋白的改变与PCOS患者胰岛素抵抗的发生、脂肪细胞的分化、细胞增殖及治疗预后有关。

关键词: 多囊卵巢综合征, PI3K-Akt, 信号传导, 胰岛素抵抗, 发病机制

Abstract: Polycystic ovary syndrome (PCOS) is a common endocrine disease, with reproductive functional disturbance and metabolic disorders. However, its etiology and pathogenesis are not clear yet. Inside the cell, phosphatidylinositol 3-kinase/Protein Kinase B (PI3K-Akt) is one of the important signal pathway, and the change of PI3K-Akt signal pathway is related to processes of PCOS, such as insulin resistance, adipocyte differentiation, cell proliferation, treatment and prognosis.

Key words: polycystic ovary syndrome, PI3K-Akt, signal transduction, insulin resistance, pathogenesis

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