基础医学与临床 ›› 2015, Vol. 35 ›› Issue (7): 980-984.

• 短篇综述 • 上一篇    下一篇

肥胖状态下不同组织细胞与自噬关系的研究进展

冯欢欢,宋向凤   

  1. 新乡医学院
  • 收稿日期:2014-11-14 修回日期:2015-01-22 出版日期:2015-07-05 发布日期:2015-06-23
  • 通讯作者: 宋向凤 E-mail:xfsong@xxmu.edu.cn

The progress of realationship between different tissue cell and autophagy under obese state

  • Received:2014-11-14 Revised:2015-01-22 Online:2015-07-05 Published:2015-06-23

摘要: 近年来越来越多的关注投向肥胖与自噬之间关系的研究,肥胖状态下机体不同组织细胞中的自噬发挥不同的作用。脂肪细胞特异性自噬基因Atg7和Atg5被敲除后脂滴积累减少,胰岛素抵抗得到改善;肝细胞中增加自噬可以提高其代谢功能:胰岛β-细胞中自噬缺陷可损伤细胞功能:适宜的自噬水平对维持骨骼肌内环境的稳态至关重要。

关键词: 肥胖, 脂肪细胞, 肝细胞, 自噬

Abstract: In recent years, it has been attracting more and more attention to the relationship between obesity and autophagy. Autophagy in different tissue cell plays a different role under the obese state. Adipose-specific deletion of autophagy-related gene 7 and gene 5 have reduced the accumulation of lipid droplets and improved insulin resistance;Increased autophagy in hepatocytes may improve the metabolism;Autophagy defects in pancreatic β-cells may damage cells function;The appropriate level of autophagy is very important to maintain the function of skeletal muscle homeostasis.

Key words: Obesity, Adipocyte, Hepatocyte, Autophagy

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