基础医学与临床 ›› 2015, Vol. 35 ›› Issue (4): 549-553.

• 短篇综述 • 上一篇    下一篇

IL-37及其与疾病相关性的研究进展

张燕1,熊霞2   

  1. 1. 泸州医学院
    2. 泸州医学院附属医院
  • 收稿日期:2014-07-30 修回日期:2014-11-28 出版日期:2015-04-05 发布日期:2015-04-08
  • 通讯作者: 熊霞 E-mail:xiongxia789@126.com

Research progress on IL - 37 and the correlation with diseases

  • Received:2014-07-30 Revised:2014-11-28 Online:2015-04-05 Published:2015-04-08

摘要: 白细胞介素-37(inteleukin-37, IL-37)是一种新型炎性抑制因子,目前发现IL-37通过抑制促炎性细胞因子、趋化因子等的产生及对基因转录的调节,参与免疫和炎性反应,在多种炎性反应及免疫相关性疾病中起重要作用,为这些疾病提供新的治疗思路和新靶点。

关键词: IL-37, 炎性反应肠病, 肝炎, 内毒素性休克, 急性冠脉综合征, 肥胖症, SLE, 银屑病

Abstract: Interleukin-37 (inteleukin -37,IL-37) is considered as a novel anti-inflammatory cytokine which involved in the immune and inflammatory response by inhibiting pro-inflammatory cytokines and chemokines, regulating gene transcription.At present, IL-37 plays an important role in a variety of inflammatory and immune related diseases,and it will provide new ideas and new treatment targets for these diseases.

Key words: IL - 37, inflammatory bowel disease, hepatitis, endotoxin shock, acute coronary syndrome, obesity, SLE, psoriasis

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