基础医学与临床 ›› 2015, Vol. 35 ›› Issue (4): 545-548.
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陈苗,韩冰
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摘要： 端粒缩短是遗传性或获得性骨髓衰竭的共同途径之一。基因突变导致端粒缩短，减少造血干细胞数量和增殖能力，导致骨髓低增生。环境因素打破代偿造血平衡，导致骨髓衰竭。
关键词: 端粒, 端粒酶, 骨髓衰竭性疾病
Abstract: Telomere shortening is one of the common ways to hereditary or acquired bone marrow failure. Telomere shortening caused by gene mutations reduces the number and proliferation of hematopoietic stem cells, and leads to bone marrow hypoplasia. Environmental factors break compensatory hematopoietic balance and lead to bone marrow failure.
Key words: telomere, telomerase, bone marrow failure diseases
陈苗 韩冰. 端粒和骨髓衰竭性疾病研究进展[J]. 基础医学与临床, 2015, 35(4): 545-548.
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