基础医学与临床 ›› 2015, Vol. 35 ›› Issue (12): 1705-1708.
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韩红梅,朴熙绪
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摘要： 非酒精性脂肪性肝炎（NASH）是非酒精性脂肪性肝病（NAFLD）的最重要形式，可发展为肝硬化和肝癌。在啮齿类动物中发现维生素D3（VD3）具有抗氧化、抗凋亡、抗炎和抗肝纤维化的作用。补充VD3可部分改善NASH的进展。VD3有望成为临床治疗NASH的有效药物。
关键词: 维生素D3, 非酒精性脂肪性肝炎
Abstract: Non-alcoholic steatohepatitis (NASH) is recognized as the most severe form of non-alcoholic fatty liver disease (NAFLD), with likely progression to liver cirrhosis and hepatocellular carcinoma. Vitamin D3 (VD3) has been shown to act as anti-oxidant, anti-apoptotic, anti-inflammatory and anti-fibrotic compound in rodents. VD3 supplementation partly ameliorated the NASH progression. VD3 can be an effective approach for the intervention in clinical NASH.
Key words: Vitamin D3, non-alcoholic steatohepatitis
中图分类号:
R856.5
韩红梅 朴熙绪. 维生素D3与非酒精性脂肪性肝炎的研究进展[J]. 基础医学与临床, 2015, 35(12): 1705-1708.
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