基础医学与临床 ›› 2015, Vol. 35 ›› Issue (12): 1700-1704.
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秦伟1,王文娟2
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Wei QIN,
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摘要： 目前已经获批的流感病毒疫苗的种类包括灭活病毒疫苗、减毒活病毒疫苗、重组HA疫苗等，并分析了其优缺点。面对新型流感病毒的出现和流感病毒的抗原漂移和逃逸、疫苗生产周期过长、接种老年人的免疫衰老现象，分析了未来的疫苗开发面临着的新的挑战，提出了解决问题的手段和未来流感疫苗研发的发展方向。
关键词: 流感病毒, 疫苗, 血凝素蛋白, H1N1
Abstract: Vaccination can reduce illness and lessen severity of infection. This review focuses on how currently licensed influenza vaccines are generated, such as inactivated influenza vaccine, live attenuated influenza vaccine, and recombinated HA vaccine, and explain why the biology of new influenza virus poses vaccine challenges which include long production cycles, and emerge of novel influenza virus and immunosenescence in the elderly. Vaccine approaches on the horizon that address these challenges.
Key words: Key words: Influenza, Vaccines, Hemagglutinin, H1N1
秦伟 王文娟. 流感病毒疫苗开发的新挑战和解决方法[J]. 基础医学与临床, 2015, 35(12): 1700-1704.
Wei QIN. New challenges and solutions of influenza vaccine[J]. Basic & Clinical Medicine, 2015, 35(12): 1700-1704.
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