基础医学与临床 ›› 2015, Vol. 35 ›› Issue (10): 1393-1396.

• 短篇综述 • 上一篇    下一篇

乳腺癌化疗抗性与自噬的关系研究进展

陈静瑶,李飞,余小平   

  1. 成都医学院
  • 收稿日期:2015-03-05 修回日期:2015-05-27 出版日期:2015-10-05 发布日期:2015-09-30
  • 通讯作者: 余小平 E-mail:cyggwsyxp@sina.com
  • 基金资助:
    国家自然科学基金面上项目;四川省青年科技创新研究团队项目;四川省省属高校科研创新团队项目

Progress of the relationship between autophagy and breast cancer chemotherapy resistance

  • Received:2015-03-05 Revised:2015-05-27 Online:2015-10-05 Published:2015-09-30

摘要: 不同类型乳腺癌相继出现化疗药物诱导自噬,产生治疗抵抗。自噬对肿瘤的发生具有双刃剑作用,在乳腺癌化疗中,通过与凋亡的相互作用产生治疗抵抗或促进癌细胞死亡两种相反的结果,但也可能与化疗抵抗无关。进一步探索自噬与肿瘤治疗抵抗间的关系和机制将是研究的重点。

关键词: 自噬, 乳腺癌, 化疗抵抗

Abstract: The therapy to different type of breast cancer has appeared chemoresistance successively which is induced by autophagy. Autophagy, to tumor’s generation, is a double edged sword, and it can result to chemoresistance and autophagic cell death thorough interaction with apoptosis in breast cancer chemotherapy. However, autophagy may have nothing with chemoresistance. It will be a key research point that to further explore the relationship and mechanism between autophagy and chemoresistance.

Key words: autophagy, breast cancer, chemoresistance

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