Abstract: Chemokine receptor-like 1 is sharing receptor of Chemerin and resolvin E1. After chemokine receptors 1 and its specific ligand had binded, intracellular calcium were stimulated to release, NF-κB、ERK1 and other signalings cascade activation reaction were leaded, it has been shown to be associated with inflammation, autoimmune disease, diabetes, metabolic diseases, cardiovascular diseases, bone diseases, tumors, reproductive system diseases, mental diseases and pathogenesis of liver diseases.