关键词: 系统性红斑狼疮, 抗磷脂抗体, 抗磷脂抗体相关性肾病

Abstract: Objective To investigate the clinical characteristics of lupus patients with positive antiphospholipid antibody (APL) and acute histopathologic lesion of antiphospholipid antibody associated nephropathy (APLN). Methods Data of 100 cases of Systemic Lupus Erythematosus (SLE) admitted to Peking Union Medical College Hospital from 2000 to 2005 was investigated by retrospective analysis. 7 cases of lupus patients with positive antiphospholipid antibody (APL) and acute lesion of APLN were included in the study group. The control groups were divided into control group 1 (7 cases of lupus patients with negative APL and acute lesion of APLN～like renal lesions) and control group 2 (86 cases of lupus patients without APL or APLN). Results The blood pressure and the serum creatinine at biopsy and two years later in patients in the study group were 156±13/92±9mmHg, 159±88μmol/L and 114±60μmol/L, respectively. The prevalence of high blood pressure and high serum creatinine were 85.7% and 42.8％, respectively. The blood pressure including systolic and diastolic blood pressure and mean arterial pressure, the serum creatinine level at biopsy and two years later, the prevalence of renal insufficiency were significantly higher in the study group compared with the control group 2(P<0.05). However there were no significantly different between the study group and the control group 1. Conclusions Lupus patients with APL and acute histopathologic lesion of APLN had higher blood pressure, higher serum creatinine level and poor renal prognosis.

Key words: Systemic Lupus Erythematosus, Antiphospholipid antibody, antiphoslipid antibody-associated nephropathy