Abstract: Heart Failure is a leading cause of mortality for most kinds of cardiovascular diseases. Cardiac remodeling is the milestone of heart failure. The molecular basis of cardiac remodeling and heart failure is still not clear. Most recently, accumulating evidence suggests that miRNAs are involved in cardiac remodeling and heart failure, regulate the expression of target genes and influence the development and progress of cardiac hypertrophy, cardiac fibrosis and heart failure. In the review, we summarize recent insights into the important role and prospective clinical value of miRNAs in cardiac remodeling and heart failure.