Scp2的表达和胆囊结石形成的关系

基础医学与临床 ›› 2006, Vol. 26 ›› Issue (10): 1108-1108.

Scp2的表达和胆囊结石形成的关系

安国顺王海梅巴图乌拉

北京大学医学部生化与分子生物学系北京北京中医药大学附属北京中西医结合医院北京北京中医药大学附属北京中西医结合医院北京

收稿日期:2005-08-31 修回日期:2006-04-29 出版日期:2006-10-25 发布日期:2006-10-25
通讯作者: 安国顺

Expression of Sterol Carrier Protein 2 and Its Correlation with the Gallstone Formation

Received:2005-08-31 Revised:2006-04-29 Online:2006-10-25 Published:2006-10-25

摘要/Abstract

摘要： 目的观察C57BL/6鼠胆囊结石形成过程中肝固醇载体蛋白2 mRNA水平及胆囊胆汁中胆固醇饱和指数的变化。方法 C57BL/6鼠20只，分为结石组和对照组，结石组采用1%的胆固醇饮食4周；RT-PCR方法检测肝Scp2 mRNA水平的变化；全自动生化仪检测胆脂，并计算胆固醇饱和指数。结果胆囊结石组肝Scp2 mRNA水平显著升高,胆汁胆固醇饱和指数亦显著增加。结论肝Scp2的表达及胆汁CSI的增高呈正相关。

Abstract: Objective To analyze the level of hepatic sterol carrier protein 2 (Scp2) mRNA and bile cholesterol saturation index(CSI) during gallstone information in C57BL/6 mice. Methods Twenty C57BL/6 mice were divided into two groups equally: control group and gallstone group. The gallstone group mice were fed with lithogenic diet (containing 1% cholesterol) for 4 weeks. The mRNA level of Scp2 in liver tissue was measured by RT-PCR. The content of biliary lipids and CSI were analyzed by Automatic Biochemistry Analyzer. Results The levels of Scp2 mRNA and bile CSI were significantly increased in gallstone group. Conclusion A positive correlation between the expression of liver Scp2 and bile CSI was found during gallstone formation.

安国顺王海梅巴图乌拉. Scp2的表达和胆囊结石形成的关系[J]. 基础医学与临床, 2006, 26(10): 1108-1108.

. Expression of Sterol Carrier Protein 2 and Its Correlation with the Gallstone Formation[J]. Basic & Clinical Medicine, 2006, 26(10): 1108-1108.