卡马西平对大鼠海马星形胶质细胞形态和GFAP表达的影响

基础医学与临床 ›› 2006, Vol. 26 ›› Issue (10): 1104-1104.

卡马西平对大鼠海马星形胶质细胞形态和GFAP表达的影响

李杏色柴锡庆

河北医科大学研究生院河北医科大学

收稿日期:2005-11-22 修回日期:2006-04-29 出版日期:2006-10-25 发布日期:2006-10-25
通讯作者: 李杏色

Effects of carbamazpine on morphology and GFAP expression of astrocytesin hippocampus of rats

Received:2005-11-22 Revised:2006-04-29 Online:2006-10-25 Published:2006-10-25

摘要/Abstract

摘要： 目的观察治疗剂量卡马西平对SD大鼠海马星形胶质细胞形态和胶质纤维酸性蛋白（GFAP）表达的影响。方法治疗剂量卡马西平每24h单次灌胃给药后，于不同时间点经心脏灌注，取脑；GFAP免疫组化染色测量海马GFAP阳性细胞数量及形态。结果1周组海马CA1区星形胶质细胞的形态及GFAP表达无变化，1个月组星形胶质细胞数量及GFAP表达量无明显增加，3个月组GFAP阳性细胞数显著增加(P<0.05)，达对照组的1.74倍；并伴细胞体积增大，侧支增多。结论治疗剂量的卡马西平对星形胶质细胞形态和GFAP表达的影响呈时间依赖性。

Abstract: Obiective To observe the effects of carbamazepine on morphology and glial fibrillary acidic protein (GFAP)expression of astrocytes in hippocampus of Sprague-Dawley rats.Methods Once daily intragastrically,in therapeutical dose for 1 week,1 and 3 months, the changes of astrocytic expression were observed with GFAP immunohistochemical staining. Results Compared to control group,GFAP immunoreactivity and the number of GFAP- positive astrocytes were significantly increased after 3 months of carbamazepine administration.Conclusion It is concluded that the changes of astrocytic expression induced by carbamazepine are time-dependent .

李杏色柴锡庆. 卡马西平对大鼠海马星形胶质细胞形态和GFAP表达的影响[J]. 基础医学与临床, 2006, 26(10): 1104-1104.

. Effects of carbamazpine on morphology and GFAP expression of astrocytesin hippocampus of rats[J]. Basic & Clinical Medicine, 2006, 26(10): 1104-1104.