人脑星形细胞瘤COX-2和VEGF表达及其相关性的研究

基础医学与临床 ›› 2006, Vol. 26 ›› Issue (10): 1089-1089.

人脑星形细胞瘤COX-2和VEGF表达及其相关性的研究

徐滨宋来君徐国本

郑州大学第一附属医院神经外科郑州大学第一附属医院神经外科郑州大学第一附属医院神经外科

收稿日期:2005-09-02 修回日期:2006-04-30 出版日期:2006-10-25 发布日期:2006-10-25
通讯作者: 徐滨

Expression and clinical significance of cyclooxygenase-2 and VEGF in human astrocytomas

Received:2005-09-02 Revised:2006-04-30 Online:2006-10-25 Published:2006-10-25

摘要/Abstract

摘要： 目的探讨环氧化酶-2（COX-2）和血管内皮生长因子（VEGF）在人脑星形细胞瘤中的表达及其与肿瘤临床病理分级的关系。方法通过免疫组化SP法测定COX-2和VEGF在50例人脑星形细胞瘤和10例正常脑组织中的表达。结果 COX-2、VEGF在人脑星形细胞瘤中的表达高于正常脑组织（P＜0.001）。COX-2和VEGF与人脑星形细胞瘤临床病理分级显著相关（P＜0.05）。人脑星形细胞瘤中COX-2与VEGF的表达存在相关性。结论 COX-2和VEGF参与人脑星形细胞瘤的发生、发展且与其恶性表型有关；COX-2可能与人脑星形细胞瘤的血管形成有关。

Abstract: Objective To investigate the expression of cyclooxygenase-2(COX-2) and vascular endothelial growth factor(VEGF) and their relationship with the clinicopathological characteristics of human astrocytomas.Methods Immunohistochemistry method was used to investigate the expression of COX-2 and VEGF among human astrocytoma samples (n=50) and normal brain tissue (n=10) respectively. Results The positive rate of COX-2 and VEGF was significantly different between the human astrocytomas and normal brain tissue（P＜0.01）.The expression of COX-2 in human astrocytomas was significantly related to the tumor's pathological grades（P＜0.05）.So was the expression of VEGF（P＜0.05）.The expression of VEGF was closely associated with COX-2（P＜0.01）.Conclusions COX-2 and VEGF may be involve in gliomas'occurance and development.Expression of COX-2 and VEGF protein was positively correlate with the malignant phenotype of gliomas. Key words Human astrocytomas; Cyclooxygenase-2; vascular endothelial growth factor ;immunohistochemistry

徐滨宋来君徐国本. 人脑星形细胞瘤COX-2和VEGF表达及其相关性的研究[J]. 基础医学与临床, 2006, 26(10): 1089-1089.

. Expression and clinical significance of cyclooxygenase-2 and VEGF in human astrocytomas[J]. Basic & Clinical Medicine, 2006, 26(10): 1089-1089.