严重多发伤患者血清HSP70和IFABP水平与肠功能损伤相关

doi:10.16352/j.issn.1001-6325.2025.07.0947

基础医学与临床 ›› 2025, Vol. 45 ›› Issue (7): 947-951.doi: 10.16352/j.issn.1001-6325.2025.07.0947

严重多发伤患者血清HSP70和IFABP水平与肠功能损伤相关

陶利民, 石广志^*

首都医科大学附属北京天坛医院重症医学科,北京 100070

收稿日期:2025-02-27 修回日期:2025-04-29 出版日期:2025-07-05 发布日期:2025-06-24
通讯作者: ^*shigzh@aliyun.com
基金资助:
首都卫生发展科研专项(首发2024-1-2042)

Association of serum HSP70 and IFABP levels with intestinal function damage in patients with severe multiple injuries

TAO Limin, SHI Guangzhi^*

Department of Intensive Care Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China

Received:2025-02-27 Revised:2025-04-29 Online:2025-07-05 Published:2025-06-24
Contact: ^*shigzh@aliyun.com

摘要/Abstract

摘要： 目的探究严重多发伤患者血清中热休克蛋白70(HSP70)、肠脂肪酸结合蛋白(IFABP)水平变化及其与肠功能损伤的关系。方法选取2021年12月至2023年12月,首都医科大学附属北京天坛医院收治的多发伤患者98例为患病组,根据创伤和高损伤严重程度评分(ISS)分为轻度组(n=52)和重度组(n=46),另选同期体检的健康志愿者42例为对照组。ELISA检测血清HSP70、IFABP水平;收集分析一般临床资料;多因素Logistic回归分析多发伤患者严重程度的影响因素;绘制受试者工作特征(ROC)曲线分析血清HSP70、IFABP对严重多发伤患者肠功能损伤程度的诊断价值;Spearman法分析血清HSP70、IFABP与ISS以及肠功能损伤程度的相关性。结果与对照组相比,患病组的血清HSP70、IFABP水平均显著升高(P＜0.05);重度组患者的ISS、重症监护病房(ICU)住院时间、血清HSP70、IFABP水平均高于轻度组(P＜0.05);患者ISS、ICU住院时间以及血清HSP70、IFABP水平均为影响多发伤患者严重程度的危险因素(P＜0.05);与轻度损伤组相比,重度损伤组的血清HSP70、IFABP水平显著升高(P＜0.05);HSP70、IFABP以及联合诊断患者肠功能损伤程度的AUC分别为0.837、0.817、0.950,联合诊断显著优于HSP70(Z=2.200,P＜0.05)、IFABP(Z=2.007,P＜0.05)单独诊断;血清HSP70、IFABP与ISS以及肠功能损伤程度均呈正相关(P＜0.05)。结论严重多发伤患者血清HSP70、IFABP水平均显著升高,二者水平与肠功能损伤程度密切相关,对患者肠功能损伤程度具有一定辅助诊断价值。

关键词: 严重多发伤, 热休克蛋白70, 肠脂肪酸结合蛋白, 肠功能损伤

Abstract: Objective To investigate the changes in serum level of heat shock protein 70 (HSP70), intestinal fatty acid binding protein (IFABP) in patients with severe multiple injuries and their relationship with intestinal function damage. Methods Cases data from ninety-eight patients with multiple injuries admitted to Beijing Temple of Heaven Hospital Affiliated to Capital Medical University from December 2021 to December 2023 were collected as the diseased group. They were separated into mild group (n=52) and severe group (n=46) based on the Injury Severity Score (ISS). Additionally, 42 healthy controls that underwent physical examinations were regarded as the control group. ELISA was applied to detect serum HSP70 and IFABP level. General clinical data were collected and analyzed. Multivariate Logistic regression was applied to analyze the influencing factors of the severity of multiple injuries patients. Receiver operating characteristic (ROC) curve was applied to analyze the diagnostic value of serum HSP70 and IFABP for the degree of intestinal function damage in patients with severe multiple injuries. Spearman method was applied to analyze the correlation between serum HSP70, IFABP with ISS and degree of intestinal function damage. Results Compared with the control group, serum level of HSP70 and IFABP in the diseased group was significantly increased (P＜0.05). The ISS, intensive care unit(ICU) hospitalization time, serum HSP70, and IFABP levels in the severe group were higher than those in the mild group (P＜0.05). The ISS, ICU hospitalization time, and serum level of HSP70 and IFABP were all believed to be the risk factors affecting the severity of multiple injuries patients (P＜0.05). Compared with the mild group, the serum HSP70 and IFABP level in the severe group were significantly increased (P＜0.05). The AUC of HSP70, IFABP, and combined diagnosis for the degree of intestinal function damage in patients was 0.837, 0.817, and 0.950, respectively. The combined diagnosis was obviously better than individual diagnosis of HSP70 (Z=2.200, P=0.028) and IFABP(Z=2.007,P=0.045). There was a positive correlation between serum HSP70, IFABP, with ISS, the degree of intestinal function damage(P＜0.05). Conclusions The serum level of HSP70 and IFABP in patients with severe multiple injuries are significantly increased, which are closely related to the degree of intestinal function damage. So the results may facilitate diagnoses and severity evaluation of intestinal function damage of patients.

Key words: severe multiple injuries, heat shock protein 70, intestinal fatty acid binding protein, intestinal function damage

中图分类号:

R466

陶利民, 石广志. 严重多发伤患者血清HSP70和IFABP水平与肠功能损伤相关[J]. 基础医学与临床, 2025, 45(7): 947-951.

TAO Limin, SHI Guangzhi. Association of serum HSP70 and IFABP levels with intestinal function damage in patients with severe multiple injuries[J]. Basic & Clinical Medicine, 2025, 45(7): 947-951.

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严重多发伤患者血清HSP70和IFABP水平与肠功能损伤相关

Association of serum HSP70 and IFABP levels with intestinal function damage in patients with severe multiple injuries

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