以“肾-三焦”系统诠释间充质干细胞实质

doi:10.16352/j.issn.1001-6325.2023.01.0046

基础医学与临床 ›› 2023, Vol. 43 ›› Issue (1): 46-50.doi: 10.16352/j.issn.1001-6325.2023.01.0046

• 特邀专题：成体干细胞基础创新与临床转化 • 上一篇下一篇

以“肾-三焦”系统诠释间充质干细胞实质

张晓彤¹, 赵月纯¹, 朱镕嘉², 赵春华^2*, 宋坪^1*

1.中国中医科学院广安门医院皮肤科,北京 100053;
2.中国医学科学院基础医学研究所北京协和医学院基础学院组织工程研究中心干细胞新药研发及临床转化研究北京市重点实验室 (BZ0381),北京 100005

收稿日期:2022-07-13 修回日期:2022-10-10 出版日期:2023-01-05 发布日期:2022-12-27
通讯作者: ^*songping@vip.126.com; zhaochunhua@vip.163.com
基金资助:
国家重点研发计划(2018YFA0109800);国家自然科学基金(81573984,81672313)

Interpretation of the essence of mesenchymal stem cells with the “kidney-triple energizers” system

ZHANG Xiaotong¹, ZHAO Yuechun¹, ZHU Rongjia², ZHAO Chunhua^2*, SONG Ping^1*

1. Department of Dermatology,Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053;
2. Beijing Key Laboratory of New Drug Development and Clinical Trial of Stem Cell Therapy(BZ0381) /Center of Excellence in Tissue Engineering, Institute of Basic Medical Sciences CAMS, School of Basic Medicine PUMC,Beijing 100005,China

Received:2022-07-13 Revised:2022-10-10 Online:2023-01-05 Published:2022-12-27
Contact: ^*songping@vip.126.com; zhaochunhua@vip.163.com

摘要/Abstract

摘要： 肾与三焦在结构与功能上密不可分,故此提出“肾-三焦”可能是间充质干细胞(MSCs)系统的本质,“肾-三焦”是对MSCs系统中医属性的探讨,以肾为本源、三焦为枢机,本文旨在从“肾精为体、三焦为用”的角度诠释MSCs系统的理论内涵,MSCs的形态与分布及发挥功能的物质、途径、功能均可在“肾-三焦”系统中得以体现,并通过中医药理论为指导,运用MSCs的现代研究技术,在COVID-19等难治性疾病的应用中取得了较好的效果,对中西医研究的结合进行了初步探索。

关键词: 间充质干细胞, 肾精, 三焦气化

Abstract: Kidney and triple energizers are inseparable in structure and function. Therefore, it is proposed that “kidney-triple energizers” might be the essence of mesenchymal stem cells (MSCs) system. As a cardinal, this article aims to interpret the theoretical connotation of the mesenchymal stem cell system from the perspective of “the kidney essence is the body and the triple energizers is the function”. It is reflected in the kidney-three energizers system, and guided by the theory of traditional Chinese medicine, the modern technology of MSCs has achieved good results in the application of refractory diseases such as COVID-19, and a preliminary exploration of the integration of Chinese and Western medicine research has been carried out.

Key words: mesenchymal stem cells, kidney essence, triple energizers Qi transformation

中图分类号:

R329.2

张晓彤, 赵月纯, 朱镕嘉, 赵春华, 宋坪. 以“肾-三焦”系统诠释间充质干细胞实质[J]. 基础医学与临床, 2023, 43(1): 46-50.

ZHANG Xiaotong, ZHAO Yuechun, ZHU Rongjia, ZHAO Chunhua, SONG Ping. Interpretation of the essence of mesenchymal stem cells with the “kidney-triple energizers” system[J]. Basic & Clinical Medicine, 2023, 43(1): 46-50.

参考文献 30

[1]	Heo JS, Choi Y, Kim HS, et al. Comparison of molecular profiles of human mesenchymal stem cells derived from bone marrow, umbilical cord blood, placenta and adipose tissue[J]. Int J Mol Med, 2016, 37: 115-125.
[2]	范瑛,庄晨,宋坪.基于干细胞探讨开通玄府、补肾培元法治疗银屑病[J].北京中医药,2015,34:310-312.
[3]	安星燕,陈云飞,李娜,等.现代细胞生物学研究诠释三焦器官/间充质干细胞系统的医学实质[J].基础医学与临床,2018,38:1599-1605.
[4]	王剑男.《黄帝内经》肾藏象理论集注与整理研究[D].呼和浩特:内蒙古医科大学,2021:2-3.
[5]	颜莹,杨京华,翁泽林.“三焦为原气之别使”刍议[J].四川中医,2021,39:23-26.
[6]	余亚娜,于建春,韩景献. 三焦气化与肾的相关性[C].2010年中国针灸学会脑病专业委员会、中国针灸学会循证针灸专业委员会学术大会论文集,2010:259-262.
[7]	Liu J, Gao J, Liang Z, et al. Mesenchymal stem cells and their microenvironment[J]. Stem Cell Res Ther, 2022, 13: 429.
[8]	Glenn JD, Whartenby KA. Mesenchymal stem cells:Emerg-ing mechanisms of immunomodulation and therapy[J]. World J Stem Cells, 2014, 6: 526-39.
[9]	原林,王军.筋膜学[M].北京:人民卫生出版社,2018:105-118,239.
[10]	Najar M, Raicevic G, Id Boufker H, et al. Modulated expression of adhesion molecules and galectin-1: role during mesenchymal stromal cell immunoregulatory functions[J]. Exp Hematol, 2010, 38: 922-932.
[11]	Najar M, Raicevic G, Crompot E, et al. The immunomodulatory potential of mesenchymal stromal cells[J]. J Immunother, 2016, 39: 45-59.
[12]	Wang S, Lei B, Zhang E, et al. Targeted therapy for inflammatory diseases with mesenchymal stem cells and their derived exosomes: from basic to clinics[J]. Int J Nanomed, 2022, 17:1757-1781.
[13]	Xu C, Yu P, Han X, et al. TGF-b promotes immune responses in the presence of mesenchymal stem cells[J]. J Immunol, 2014, 192: 103-109.
[14]	Ayala-Cuellar AP, Kang JH, Jeung EB,et al.Roles of mesenchymal stem cells in tissue regeneration and immunomodulation[J]. Biomol Ther, 2019, 27: 25-33.
[15]	Mezey É.Human mesenchymal stem/stromal cells in immune regulation and therapy[J]. Stem Cells Transl Med, 2022, 11: 114-134.
[16]	Yuan L, Wu MJ, Sun HY, et al. VEGF-modified human embryonic mesenchymal stem cell implantation enhances protection against cisplatin-induced acute kidney injury[J]. Am J Physiol Renal Physiol, 2011, 300: 207-218.
[17]	黄建华,卞琴,沈自尹.“肾精”涵义的再分析及其意义[J].中华中医药杂志,2012,27:522-524.
[18]	柴倩云,尹秀平,朱榕嘉,等.从间充质干细胞调控免疫平衡作用探讨中医扶正祛邪治疗银屑病[J].中医杂志,2019,60:206-209.
[19]	史志云.关于三焦实质与三焦辨证[J].广州中医学院学报,1985:34-38+43.
[20]	王琦,白明华.中医药治疗新型冠状病毒肺炎恢复期面临的问题和对策[J].中医杂志,2021,62:371-374+380.
[21]	Zhu Y, Zhu R, Liu K, et al. Human umbilical cord mesenchymal stem cells for adjuvant treatment of a critically Ⅲ COVID-19 patient: a case report[J].Infect Drug Resist, 2020, 13: 3295-3300.
[22]	Leng Z, Yin D, Zhao Z, et al. A survey of 434 clinical trials about coronavirus disease 2019 in China[J]. J Med Virol, 2020, 92: 1715-1717.
[23]	Leng Z, Zhu R, Hou W, et al. Transplantation of ACE2-mesenchymal stem cells improves the outcome of patients with COVID-19 pneumonia[J]. Aging Dis, 2020, 11, 216-228.
[24]	Yu H, Yang X, Xiao X, et al. Human adipose mesenchymal stem cell-derived exosomes protect mice from DSS-induced inflammatory bowel disease by promoting intestinal-stem-cell and epithelial regeneration[J]. Aging Dis, 2021, 12: 1423-1437.
[25]	Wang L, Han Q, Chen H, et al. Allogeneic bone marrow mesenchymal stem cell transplantation in patients with UDCA-resistant primary biliary cirrhosis[J]. Stem Cells Dev, 2014, 23: 2482-2489.
[26]	尹秀平. 从巴戟天多糖对银屑病AMSCs免疫调控的干预探讨“补肾培元”法治疗银屑病的作用机制[D].北京:中国中医科学院,2017:55-65.
[27]	张晓彤.从脂肪间充质干细胞对HaCat炎症模型的免疫调控作用探讨补益法治疗银屑病机制[D].北京:中国中医科学院,2020:64-67.
[28]	张晓彤,高云逸,宋坪.寻常型银屑病中医辨证特点概况及思考[J].中医杂志,2019,60:1732-1736.
[29]	张乃月,朱榕嘉,尹秀平,等.射干苷和桃叶珊瑚苷抑制LPS诱导的人脂肪间充质干细胞炎性反应[J].基础医学与临床,2019,39:961-966.
[30]	Niu Y, Chen Y, Xu H, et al. Astragaloside IV promotes antiphotoaging by enhancing the proliferation and paracr-ine activity of adipose-derived stem cells[J]. Stem Cells Dev, 2020, 29: 1285-1293.

以“肾-三焦”系统诠释间充质干细胞实质

Interpretation of the essence of mesenchymal stem cells with the “kidney-triple energizers” system

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