Abstract:

Infective endocarditis often leads to various vascular complications, among which cerebrovascular complications are associated with increased mortality in the early and late stages of the disease. Anticoagulant therapy for infective endocarditis is still controversial. How to balance the risk of cerebral embolism and bleeding events during the treatment is a difficult problem to define in clinical practice. This article reviews the epidemiology, pathophysiology, imaging evaluation methods and anticoagulation treatment strategies of disease-related cerebral embolism and bleeding events, in order to provide guidance for clinical anticoagulant treatment of infective endocarditis.

Key words: Endocarditis, Cerebrovascular disorders, Anticoagulants, Review

摘要：

感染性心内膜炎常导致各种血管并发症，其中脑血管并发症与疾病早期和晚期病死率增加有关。感染性心内膜炎抗凝治疗目前仍存争议，治疗过程中如何平衡脑栓塞与出血事件的风险是目前临床难以界定的难题。本文从感染性心内膜炎相关脑栓塞与出血事件的流行病学、病理生理学、影像学评估手段及抗凝治疗策略等方面进行阐述，以为疾病的抗凝治疗提供指导。

关键词: 心内膜炎, 脑血管障碍, 抗凝药, 综述