Immune checkpoint inhibitors-related nervous system adverse events

doi:10.3969/j.issn.1672-6731.2022.09.002

Abstract

Abstract: Immune checkpoint inhibitors (ICIs) have been widely used in tumor treatment. Immune-related adverse events (irAEs) are common in skin, endocrine, gastrointestinal tract, liver and cardiovascular system symptoms. Nervous system adverse events are relatively rare, but the clinical presentations are various and difficult to identify. Neurologists should strengthen their understanding of neurologic immune-related adverse events (NirAEs), so as to enable the events to be identified in time, intervene as early as possible, and closely monitor the events, in order to improve the disease prognosis.

Key words: Neoplasms, Immunosuppressive agents, Drug-related side effects and adverse reactions, Nervous system, Review

摘要： 免疫检查点抑制剂广泛用于肿瘤的治疗，与其相关的药物不良反应以皮肤、内分泌、胃肠道、肝脏和心血管系统症状常见，神经系统不良反应虽相对少见，但种类、表现多样，不易识别。了解免疫检查点抑制剂相关神经系统不良反应的发生机制，有助于提高对其认知程度，尽早识别、准确诊断、及时干预、严密监控，最大程度改善患者预后。

关键词: 肿瘤, 免疫抑制剂, 药物相关性副作用和不良反应, 神经系统, 综述

WANG Ze-yi, LIU Guang-zhi. Immune checkpoint inhibitors-related nervous system adverse events[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2022, 22(9): 752-756.

王泽祎, 刘广志. 免疫检查点抑制剂相关神经系统不良反应[J]. 中国现代神经疾病杂志, 2022, 22(9): 752-756.

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URL: http://journal11.magtechjournal.com/cjcnn/EN/10.3969/j.issn.1672-6731.2022.09.002

http://journal11.magtechjournal.com/cjcnn/EN/Y2022/V22/I9/752

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