Abstract:

About 1/3 of patients with major depression cannot benefit from regular antidepressant therapy, psychotherapy and cognitive behavioral treatment (CBT). Currently, deep brain stimulation (DBS), as a new treatment, has been used to treat major depression. However, only a few medical centers have performed DBS in major depression, and the number of cases is limited. DBS for treating major depression is still in clinical trial stage due to unclear mechanism, lacking of effective stimulation targets, no uniform stimulation parameters, and controversial efficacy. This article reviews mechanism, indications, stimulation parameters, curative effect, complications and future trends of DBS in the treatment of major depression.

Key words: Depressive disorder, Deep brain stimulation, Review

摘要：

近1/3的重度抑郁症患者对正规抗抑郁治疗、心理治疗和认知行为疗法无效。脑深部电刺激术治疗重度抑郁症作为一种新的方法，仅在少数医学中心开展，病例数较少。其作用机制尚不明确，缺乏有效的靶点核团，刺激参数尚不统一，疗效仍存争议，尚处于临床试验阶段。本文拟对脑深部电刺激术治疗重度抑郁症的作用机制、适应证、刺激参数、手术疗效和并发症以及未来发展趋势进行综述。

关键词: 抑郁症, 深部脑刺激法, 综述