Chinese Journal of Contemporary Neurology and Neurosurgery ›› 2017, Vol. 17 ›› Issue (7): 500-506. doi: 10.3969/j.issn.1672-6731.2017.07.005

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Application of gene detection in precision medicine of cerebrovascular disease

ZHE Xiao1, DENG Yan-chun2   

  1. 1Department of Neurology, the First Affiliated Hospital of Xi'an Medical University, Xi'an 710077, Shaanxi, China
    2Department of Neurology, Xijing Hospital, the Fourth Military Medical University of Chinese PLA, Xi'an 710032, Shaanxi, China
  • Online:2017-07-25 Published:2017-08-02
  • Contact: DENG Yan-chun (Email: yanchund@fmmu.edu.cn)
  • Supported by:

    This study was supported by 2010 Science and Research Special Project of Shaanxi Provincial Education Department (No. 2010JK811) and Science and Technology Project of Lianhu District, Shaanxi Province, China (No. K2011-024).

基因检测在脑血管病精准医疗中的应用

折潇, 邓艳春   

  1. 710077 西安医学院第一附属医院神经内科(折潇);710032 西安,第四军医大学西京医院神经内科(邓艳春)
  • 通讯作者: 邓艳春(Email:yanchund@fmmu.edu.cn)
  • 基金资助:

    陕西省教育厅2010 年专项科学研究项目计划(项目编号:2010JK811);陕西省西安市莲湖区科技计划项目(项目编号:K2011-024)

Abstract:

Precision medicine (PM), a new type of medical concept and model which based on personalized medicine, is developed with the fast progress of genetic detection technology and the cross-application of biological information and large data science. Genetic detection technology is the basis of PM. Cerebrovascular disease is a multifactorial disease, in which genetic factors play an important role in the pathogenesis. This paper intends to discuss the application of gene detection technology in the PM of cerebrovascular disease, including single gene genetic disease, genetic polymorphism, drug genetics research and precision treatment.

Key words: Cerebrovascular disorders, Genes, Review

摘要:

精准医疗是以个体化医疗为基础、随着基因检测技术快速进步以及生物学信息和大数据科学交叉应用而发展起来的新型医学概念与医疗模式。基因检测技术是精准医疗的基础。脑血管病是遗传因素和环境因素相互作用的多因素疾病,其中遗传因素发挥重要作用。本文拟从单基因遗传病、基因多态性、药物遗传学研究和精准治疗等方面阐述基因检测在脑血管病精准医疗中的应用。

关键词: 脑血管障碍, 基因, 综述