Abstract:

Parkinson's disease (PD) is a common neurodegenerative disease. It is characterized by a combination of motor symptoms and non-motor symptoms (NMS) based on clinical symptoms. More and more attention has been drawn to olfactory dysfunction as an early NMS in PD. It is believed that nicotine in cigarettes may lower the risk of getting PD and people with smoking history may have lower risk of olfactory dysfunction. So smoking may have protective effect on PD. The effect of smoking on olfactory function in PD patients may lead us to have a better understanding of the pathogenesis of PD.

Key words: Smoking, Parkinson disease, Olfaction disorders, Review

摘要：

帕金森病是临床常见的神经变性病，根据临床症状可以分为运动症状和非运动症状，嗅觉障碍作为帕金森病最常见的非运动症状越来越受到重视。既往研究显示，尼古丁可能降低帕金森病发病风险，而有吸烟史的帕金森病患者嗅觉障碍轻微，因此吸烟可能通过嗅觉系统对帕金森病产生保护作用。吸烟对帕金森病患者嗅觉功能的影响可能有助于我们更全面地了解帕金森病发病过程。

关键词: 吸烟, 帕金森病, 嗅觉障碍, 综述