Abstract: Stroke is a common disease which has serious impact on human health in modern society. It has complex pathogenesis and wide-ranging influencing factors. Accompanied with the development of molecular genetics, a number of single nucleotide polymorphisms (SNPs) have been found to be closely related to the incidence of stroke in case-control studies on the correlation between genes and stroke by using molecular biology technologies. In order to have a better understanding on the correlation between gene polymorphism and stroke, this summary presents a review of literatures reported at home and abroad over the past year on the genetics of stroke.

Key words: Stroke, Genes, Polymorphism, genetic, Review

摘要： 脑卒中是当今社会严重威胁人类健康的常见病，其发病机制复杂、影响因素广泛。近年来，随着分子遗传学的发展，利用分子生物学技术对基因与脑卒中相关性进行病例对照研究，许多单核苷酸多态性被发现与脑卒中的发病密切相关。为了更好地揭示基因多态性与脑卒中的关联性，本文对近一年来国内外相关研究进行综述，以期更详尽地了解脑卒中致病基因的研究进展。

关键词: 卒中, 基因, 多态现象, 遗传, 综述