Chinese Journal of Contemporary Neurology and Neurosurgery ›› 2015, Vol. 15 ›› Issue (11): 852-858. doi: 10.3969/j.issn.1672-6731.2015.11.003

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Research progress on pathological changes of brain caused by status epilepticus

ZHANG Le, BI Fang-fang, SHU Yi, TANG Wei-ting, YANG Ming   

  1. Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, Hu'nan, China
  • Online:2015-11-25 Published:2015-11-26
  • Contact: ZHANG Le (Email: zlzdzlzd@163.com)
  • Supported by:

    This study was supported by National Natural Science Foundation of China (No. 81571151) and National Natural Science Foundation for Young Scholars of China (No. 81401078).

癫痫持续状态病理学研究进展

张乐, 毕方方, 舒怡, 唐薇婷, 杨铭   

  1. 410008 长沙,中南大学湘雅医院神经内科
  • 通讯作者: 张乐(Email:zlzdzlzd@163.com)
  • 基金资助:

    国家自然科学基金资助项目(项目编号:81571151);国家自然科学基金青年科学基金资助项目(项目编号:81401078)

Abstract:

Status epilepticus (SE) is a common neurological emergency with high disability and mortality rates. The degree of brain injury after SE is a key factor related to the prognosis of patients. The specific mechanism of brain injury after SE could be studied by combining pathological changes and molecular level changes. This paper summarizes the research progress of SE pathology and the underlying mechanism to provide a theoretical basis to explore new therapies and diagnostic methods of SE.

Key words: Status epilepticus, Pathology, Review

摘要:

癫痫持续状态为病死率和病残率较高的中枢神经系统常见急危重症,其引起的脑损伤严重程度是影响患者预后的重要因素。从癫痫持续状态诱发的脑组织病理改变角度结合分子水平加以研究,有望揭示其脑损伤机制,为探索癫痫持续状态新的预测与治疗方法提供理论依据。

关键词: 癫痫持续状态, 病理学, 综述