Abstract: This paper reviewed the latest findings related to secondary restless legs syndrome (RLS) systematically. There were a variety of causes. Renal failure, injury of spinal cord and peripheral nerve were related risk factors. During pregnancy, the levels of folic acid and iron diminished and many hormone levels underwent significant changes, which might also be predisposing factors for RLS. The underlying dopamine dysfunction might affect Pakinson's disease (PD) patients with RLS symptoms. In addition, there were some evidences which would illustrate some drugs (mainly antidepressants, antipsychotics, histamine receptor antagonist), smoking, caffeine, alcohol and migraine might be associated with the prevalence of RLS, or even the severity of the disease. Clinicians should pay more attention to early diagnosis and treatment plan to improve the quality of life of these patients.

Key words: Restless legs syndrome, Review

摘要： 本文回顾继发性不宁腿综合征的相关研究结果，介绍其常见病因。经研究显示，有多种因素可能与继发性不宁腿综合征的发生发展和严重程度相关，如肾衰竭、脊髓和周围神经病变、妊娠所致铁和叶酸缺乏及相应性激素变化；帕金森病多巴胺能系统功能紊乱；某些药物（抗抑郁药、抗精神病药、组胺受体阻断药）；吸烟、饮酒；咖啡因；偏头痛等。临床应详细询问病史，去除病因，提高患者生活质量。

关键词: 不宁腿综合征, 综述