Adult paraneoplastic opsoclonus-myoclonus-ataxia syndrome: one case report

doi:10.3969/j.issn.1672-6731.2024.07.014

Abstract

Key words: Ocular motility disorders, Myoclonus, Ataxia, Paraneoplastic syndromes, nervous system, Case reports

关键词: 眼球运动障碍, 肌阵挛, 共济失调, 副肿瘤综合征，神经系统, 病例报告

Dong-xin WANG, Hai-li LU, Na CHEN. Adult paraneoplastic opsoclonus-myoclonus-ataxia syndrome: one case report[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2024, 24(7): 583-588.

王冬欣, 卢海丽, 陈娜. 成人副肿瘤性眼阵挛-肌阵挛-共济失调综合征一例[J]. 中国现代神经疾病杂志, 2024, 24(7): 583-588.

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URL: http://journal11.magtechjournal.com/cjcnn/EN/10.3969/j.issn.1672-6731.2024.07.014

http://journal11.magtechjournal.com/cjcnn/EN/Y2024/V24/I7/583

Figures/Tables 3

References 43

1	Huang XJ , Ge L , Wu JM , Zhou ZM . Adult paraneoplastic strabismus opsoclonus-myoclonus syndrome: one case report. Lin Chuang Shen Jing Bing Xue Za Zhi, 2016, 29: 318. URL
	黄显军, 葛良, 吴家幂, 周志明. 成人副肿瘤斜视性眼肌阵挛-肌阵挛1例报道. 临床神经病学杂志, 2016, 29: 318. URL
2	Miraclin AT , Mani AM , Sivadasan A , Nair A , Christina M , Gojer AR , Milton S , Jude Prakash JA , Benjamin RN , Prabhakar AT , Mathew V , Aaron S . Opsoclonus myoclonus ataxia syndrome, ovarian teratoma and anti-NMDAR antibody: an'unresolved'mystery. BMJ Neurol Open, 2023, 5: e000414. doi: 10.1136/bmjno-2023-000414
3	Huang M . Strabismus ocular myoclonus-myoclonus paraneoplastic syndrome caused by bladder cancer: a case report. Zhejiang Yi Xue, 2021, 43: 1245. doi: 10.12056/j.issn.1006-2785.2021.43.11.2020-3703
	黄敏. 膀胱癌引起的斜视性眼肌阵挛-肌阵挛副肿瘤综合征1例. 浙江医学, 2021, 43: 1245. doi: 10.12056/j.issn.1006-2785.2021.43.11.2020-3703
4	Graus F , Delattre JY , Antoine JC , Dalmau J , Giometto B , Grisold W , Honnorat J , Smitt PS , Vedeler Ch , Verschuuren JJ , Vincent A , Voltz R . Recommended diagnostic criteria for paraneoplastic neurological syndromes. J Neurol Neurosurg Psychiatry, 2004, 75: 1135- 1140. doi: 10.1136/jnnp.2003.034447
5	Graus F , Vogrig A , Muñiz-Castrillo S , Antoine JG , Desestret V , Dubey D , Giometto B , Irani SR , Joubert B , Leypoldt F , McKeon A , Prüss H , Psimaras D , Thomas L , Titulaer MJ , Vedeler CA , Verschuuren JJ , Dalmau J , Honnorat J . Updated diagnostic criteria for paraneoplastic neurologic syndromes. Neurol Neuroimmunol Neuroinflamm, 2021, 8: e1014. doi: 10.1212/NXI.0000000000001014
6	Rong YT , Yu F , Xu L . Clinical analysis of 17 cases of paraneoplastic syndrome of nervous system. Zhonghua Quan Ke Yi Xue, 2020, 18: 902- 905. URL
	荣玉婷, 余锋, 许力. 17例神经系统副肿瘤综合征临床分析. 中华全科医学, 2020, 18: 902- 905. URL
7	Sena G , Gallo G , Vescio G , Gambardella D , de Franciscis S , Renne M . Anti-Ri-associated paraneoplastic ophthalmoplegia-ataxia syndrome in a woman with breast cancer: a case report and review of the literature. J Med Case Rep, 2020, 14: 67. doi: 10.1186/s13256-020-02410-z
8	Sharma C , Acharya M , Kumawat BL , Kochar A . 'Dancing eyes, dancing feet syndrome'in small cell lung carcinoma. BMJ Case Rep, 2014, bcr2014203926. doi: 10.1136/bcr-2014-203926
9	Klaas JP , Ahlskog JE , Pittock SJ , Matsumoto JY , Aksamit AJ , Bartleson JD , Kumar R , McEvoy KF , McKeon A . Adult-onset opsoclonus-myoclonus syndrome. Arch Neurol, 2012, 69: 1598- 1607. doi: 10.1001/archneurol.2012.1173
10	ArmanguéT , Sabater L , Torres-Vega E , Martínez-Hernández E , Ariño H , Petit-Pedrol M , PlanagumàJ , Bataller L , Dalmau J , Graus F . Clinical and immunological features of opsoclonus-myoclonus syndrome in the era of neuronal cell surface antibodies. JAMA Neurol, 2016, 73: 417- 424. doi: 10.1001/jamaneurol.2015.4607
11	Oh SY , Kim JS , Dieterich M . Update on opsoclonus-myoclonus syndrome in adults. J Neurol, 2019, 266: 1541- 1548. doi: 10.1007/s00415-018-9138-7
12	Nwafor DC , Petrone AB , Collins JM , Adcock AK . Paraneoplastic opsoclonus myoclonus in a patient with pancreatic adenocarcinoma. Case Rep Neurol Med, 2019, ID3601026.
13	Bataller L , Graus F , Saiz A , Vilchez JJ; Spanish Opsoclonus-Myoclonus Study Group . Clinical outcome in adult onset idiopathic or paraneoplastic opsoclonus-myoclonus. Brain, 2001, 124 (Pt 2): 437- 443.
14	Luque FA , Furneaux HM , Ferziger R , Rosenblum MK , Wray SH , Schold SC Jr , Glantz MJ , Jaeckle KA , Biran H , Lesser M , Paulsen WA , River ME , Posner JB . Anti-Ri: an antibody associated with paraneoplastic opsoclonus and breast cancer. Ann Neurol, 1991, 29: 241- 251. doi: 10.1002/ana.410290303
15	Hébert J , Armstrong D , Daneman N , Jain JD , Perry J . Adult-onset opsoclonus-myoclonus syndrome due to West Nile Virus treated with intravenous immunoglobulin. J Neurovirol, 2017, 23: 158- 159. doi: 10.1007/s13365-016-0470-3
16	Emamikhah M , Babadi M , Mehrabani M , Jalili M , Pouranian M , Daraie P , Mohaghegh F , Aghavali S , Zaribafian M , Rohani M . Opsoclonus-myoclonus syndrome, a post-infectious neurologic complication of COVID-19:case series and review of literature. J Neurovirol, 2021, 27: 26- 34. doi: 10.1007/s13365-020-00941-1
17	Shah NS , Pathak J , Shah PC , Bharmal UF , Ansari MI . A rare case of opsoclonus myoclonus ataxia syndrome post viral illness. Cureus, 2023, 15: e40396.
18	Kostoglou A , Vlastos D , Bakalis A , Ghosh D . Breast cancer-associated opsoclonus-myoclonus syndrome: a case report. World J Surg Oncol, 2021, 19: 328. doi: 10.1186/s12957-021-02436-7
19	Zeng Q , Zeng ZX . Clinical analysis of 36 cases with paraneoplastic neurological syndrome. Zhongguo Ye Jin Gong Ye Yi Xue Za Zhi, 2018, 35: 132- 133. URL
	曾倩, 曾昭祥. 神经系统副肿瘤综合征36例临床分析. 中国冶金工业医学杂志, 2018, 35: 132- 133. URL
20	Liu BZ . Adult strabismic paraneoplastic opsoclonus-myoclonus ataxia syndrome: one case report. Lin Chuang Shen Jing Bing Xue Za Zhi, 2005, 18: 152. doi: 10.3969/j.issn.1004-1648.2005.02.038
	刘步珍. 副肿瘤综合征致斜视眼阵挛-肌阵挛共济失调1例报告. 临床神经病学杂志, 2005, 18: 152. doi: 10.3969/j.issn.1004-1648.2005.02.038
21	Jones AA , Chen T . Delayed opsoclonus-myoclonus syndrome after ovarian teratoma resection. J Neuroophthalmol, 2022, 42: e450- e451. doi: 10.1097/WNO.0000000000001384
22	Taib BG , Kinshuck AJ , Milburn-McNulty P , Fratalia L , Forsyth L , Husband D , Jones TM , Jacob A . Opsoclonus-myoclonus syndrome associated with a nasopharyngeal tumor in an adult: a case report. J Med Case Rep, 2015, 9: 128. doi: 10.1186/s13256-015-0605-9
23	Blaes F , Jauss M , Kraus J , Oschmann P , Krasenbrink I , Kaps M , Teegen B . Adult paraneoplastic opsoclonus-myoclonus syndrome associated with antimitochondrial autoantibodies. J Neurol Neurosurg Psychiatry, 2003, 74: 1595- 1596. doi: 10.1136/jnnp.74.11.1595
24	Rosenow CS , Dawit S , Farrugia LP , Henry Ma KA , Sharma A , McKeon A , Porter AB , Grill MF . Case report: opsoclonus-myoclonus syndrome associated with contactin-associated protein-like 2 and acetylcholine receptor autoantibodies in the setting of non-small cell lung carcinoma. Neurohospitalist, 2022, 12: 100- 104. doi: 10.1177/19418744211012899
25	Grubbs J Jr , Trobe JD , Fisher-Hubbard A . Opsoclonus-myoclonus syndrome in primary central nervous system lymphoma. J Neuroophthalmol, 2016, 36: 408- 411. doi: 10.1097/WNO.0000000000000359
26	Stewart KT , Lee JS , Stuart G . Paraneoplastic opsoclonus-myoclonus syndrome as a presentation of high grade serous ovarian cancer. Gynecol Oncol Rep, 2019, 30: 100511. doi: 10.1016/j.gore.2019.100511
27	Mahesh KV , Bansal R , Naheed D , Tandyala N , Singh R , Takkar A . Opsoclonus myoclonus syndrome due to an ovarian teratoma: a case report and review of literature. Neuroophthalmology, 2019, 44: 258- 261.
28	Martins L , Galvão D , Silva A , Vieira B , ReisÓ , Vitorino R , Pires P . Paraneoplastic opsoclonus-myoclonus syndrome as a rare presentation of breast cancer. J Surg Case Rep, 2019, 2019: rjy365.
29	Laroumagne S , Elharrar X , Coiffard B , Plojoux J , Dutau H , Breen D , Astoul P . "Dancing eye syndrome" secondary to opsoclonus-myoclonus syndrome in small-cell lung cancer. Case Rep Med, 2014, ID545490.
30	Musunuru K , Kesari S . Paraneoplastic opsoclonus-myoclonus ataxia associated with non-small-cell lung carcinoma. J Neurooncol, 2008, 90: 213- 216. doi: 10.1007/s11060-008-9650-1
31	Moreira I , Vilas-Boas I , Cassiano Neves M . Paraneoplastic opsoclonus-myoclonus syndrome as a rare presentation of small-cell lung cancer. Cureus, 2022, 14: e32066.
32	Reinecke R , Reiländer A , Seiler A , Koch C , Voss M . Opsoclonus-myoclonus syndrome associated with pancreatic neuroendocrine tumor: a case report. BMC Neurol, 2022, 22: 507. doi: 10.1186/s12883-022-03012-6
33	Soares R , Mittapalli A , Ramakrishnan M , Farooq U . Breast cancer presenting as onconeural antibody negative opsoclonus-myoclonus syndrome. Cureus, 2022, 14: e28417.
34	Flanagan EP . Paraneoplastic disorders of the nervous system. Continuum (Minneap Minn), 2020, 26: 1602- 1628.
35	Giometto B , Grisold W , Vitaliani R , Graus F , Honnorat J , Bertolini G; PNS Euronetwork . Paraneoplastic neurologic syndrome in the PNS Euronetwork database: a European study from 20 centers. Arch Neurol, 2010, 67: 330- 335. doi: 10.1001/archneurol.2009.341
36	Budde-Steffen C , Anderson NE , Rosenblum MK , Graus F , Ford D , Synek BJ , Wray SH , Posner JB . An antineuronal autoantibody in paraneoplastic opsoclonus. Ann Neurol, 1988, 23: 528- 531. doi: 10.1002/ana.410230518
37	Li ZC , Ge CM . Advances in the study of nervous system paraneoplastic syndrome with positive anti Ri antibody. Yi Nan Bing Za Zhi, 2022, 21: 1113- 1116. URL
	李自超, 葛朝明. 抗Ri抗体阳性的神经系统副肿瘤综合征研究进展. 疑难病杂志, 2022, 21: 1113- 1116. URL
38	Boch M , Rinke A , Rexin P , Seipelt M , Brödje D , Schober M , Gress TM , Michl P , Krug S . Paraneoplastic brainstem encephalitis in a patient with exceptionally long course of a metastasized neuroendocrine rectum neoplasm. BMC Cancer, 2014, 14: 691. doi: 10.1186/1471-2407-14-691
39	Mitchell AN , Bakhos CT , Zimmerman EA . Anti-Ri-associated paraneoplastic brainstem cerebellar syndrome with coexisting limbic encephalitis in a patient with mixed large cell neuroendocrine lung carcinoma. J Clin Neurosci, 2015, 22: 421- 423. doi: 10.1016/j.jocn.2014.06.103
40	Said S , Cooper CJ , Reyna E , Alkhateeb H , Diaz J , Nahleh Z . Paraneoplastic limbic encephalitis, an uncommon presentation of a common cancer: case report and discussion. Am J Case Rep, 2013, 14: 391- 394. doi: 10.12659/AJCR.889560
41	Pranzatelli MR . The neurobiology of the opsoclonus-myoclonus syndrome. Clin Neuropharmacol, 1992, 15: 186- 228. doi: 10.1097/00002826-199206000-00002
42	Murphy BL , Zalewski NL , Degnim AC , McKeon A , Flanagan EP , Pittock SJ , Habermann EB . Breast cancer-related paraneoplastic neurologic disease. Breast Cancer Res Treat, 2018, 167: 771- 778. doi: 10.1007/s10549-017-4566-0
43	Jin MH , Bai SF , Zhai MM , Cheng LN . Paraneoplastic cerebellar degeneration with anti-SOX1 antibody: one case report and literature review. Zhong Feng Yu Shen Jing Ji Bing Za Zhi, 2019, 36: 651- 653. URL
	金梦华, 白树风, 翟明明, 程丽妞. 抗SOX1抗体阳性副肿瘤性小脑变性1例并文献复习. 中风与神经疾病杂志, 2019, 36: 651- 653. URL

序号	文献来源	性别	年龄（岁）	临床表现	抗体	肿瘤类型	治疗	预后
1	黄敏^[3]（2021）	男性	65	眼阵挛、肌阵挛、共济失调	-	膀胱癌	原发肿瘤治疗、IVIg	部分缓解
2	黄显军等^[1]（2016）	男性	61	头晕、眼阵挛、肌阵挛、睡眠障碍、精神症状	-	肺癌	糖皮质激素、氯硝西泮	部分缓解
3	刘步珍^[20]（2005）	男性	63	眼阵挛、肌阵挛、共济失调	—	小细胞肺癌	原发肿瘤治疗	完全缓解
4	Jones和Chen^[21]（2022）	女性	27	恶心、头晕、步态不稳、眼阵挛、体位性震颤、动作性肌阵挛、宽基步态	-	卵巢癌	糖皮质激素、IVIg、利妥昔单抗	迅速缓解，随访30个月无复发
5	Miraclin等^[2]（2023）	女性	28	共济失调、全身震颤、肌阵挛、癫痫发作、精神行为异常，睡眠障碍	-	卵巢畸胎瘤	原发肿瘤治疗、糖皮质激素	完全缓解，随访2年所有日常生活活动均可独立完成
6	Kostoglou等^[18]（2021）	女性	43	癫痫发作、眼球运动障碍、共济失调、幻听、失眠	抗Ri抗体（+）	乳腺癌	血浆置换、糖皮质激素	部分缓解
7	Taib等^[22]（2015）	女性	50	头晕、精神错乱、步态不稳、眼阵挛、肌阵挛、小脑功能障碍	-	鼻咽癌	原发肿瘤治疗、糖皮质激素、IVIg	部分缓解
8	Blaes等^[23]（2003）	女性	58	斜视性眼阵挛、肌阵挛、共济失调	AMA（+）	小细胞肺癌	原发肿瘤治疗、糖皮质激素	遗留轻度共济失调
9	Rosenow等^[24]（2022）	女性	46	恶心、呕吐、眩晕、构音障碍、肌阵挛、眼阵挛、步态不稳	肌肉乙酰胆碱受体结合抗体（+），抗CASPR2抗体（+）	肺癌	原发肿瘤治疗、血浆置换、糖皮质激素、IVIg	死亡
10	Nwafor等^[12]（2019）	女性	72	眼阵挛、腹肌阵挛、共济失调	抗VGKC抗体（+）	胰腺癌	原发肿瘤治疗、糖皮质激素、劳拉西泮、左乙拉西坦	死亡
11	Sena等^[7]（2020）	女性	72	视物模糊、复视、步态障碍	抗Ri抗体（+）	乳腺癌	原发肿瘤治疗	部分缓解
12	Grubbs等^[25]（2016）	女性	53	眼阵挛、肌阵挛、抽搐、失衡、言语不清、认知功能减退	-	DLBCL	IVIg、糖皮质激素、甲氨蝶呤、长春新碱、利妥昔单抗	死亡
13	Stewart等^[26]（2019）	女性	54	肢体震颤、斜视性眼阵挛、面部和双上肢肌强直性抽搐	抗Ri抗体（+）	卵巢癌	原发肿瘤治疗、糖皮质素、氯硝西泮	神经系统症状完全缓解，随访10年未复发但肿瘤复发
14	Mahesh等^[27]（2019）	女性	14	斜视性眼阵挛、肌阵挛、共济失调	-	卵巢畸胎瘤	原发肿瘤治疗、IVIg、糖皮质激素	完全缓解
15	Martins等^[28]（2019）	女性	49	睡眠障碍、眼阵挛、肌阵挛、共济失调	抗Ri抗体（+）	乳腺癌	原发肿瘤治疗、他莫昔芬、糖皮质激素、利妥昔单抗、氯硝西泮、左乙拉西坦	6个月后抗Ri抗体转阴，未复发
16	Laroumagne等^[29]（2014）	男性	65	共济失调、肌阵挛、眼球震颤	抗GAD65抗体（+）	小细胞肺癌	原发肿瘤治疗、糖皮质激素	死亡
17	Musunuru等^[30]（2008）	女性	63	恶心、眩晕、构音障碍、步态不稳、斜视性眼阵挛、肌阵挛	抗Ri抗体（+）	非小细胞肺癌	原发肿瘤治疗、糖皮质激素	死亡
18	Moreira等^[31]（2022）	男性	69	眩晕、恶心、呕吐、构音障碍、眼球震颤、肌阵挛、共济失调	-	小细胞肺癌	原发肿瘤治疗、糖皮质激素	死亡
19	Reinecke等^[32]（2022）	女性	33	恶心、呕吐、头部震颤、构音障碍、肌阵挛、斜视性眼阵挛、共济失调	-	胰腺神经内分泌肿瘤	糖皮质激素、血浆置换	遗留共济失调
20	Soares等^[33]（2022）	女性	53	眩晕、恶心、呕吐、四肢抽搐、精运动不能、步态异常	-	乳腺癌	原发肿瘤治疗、糖皮质激素、利妥昔单抗	3个月后偶尔出现眩晕和轻微手部震颤
21	本文患者	女性	56	头晕、眼阵挛、肌阵挛、共济失调	抗Ri抗体（+）	无	IVIg、糖皮质激素	16个月后死于肺部感染

序号	文献来源	性别	年龄（岁）	临床表现	抗体	肿瘤类型	治疗	预后
1	黄敏^[3]（2021）	男性	65	眼阵挛、肌阵挛、共济失调	-	膀胱癌	原发肿瘤治疗、IVIg	部分缓解
2	黄显军等^[1]（2016）	男性	61	头晕、眼阵挛、肌阵挛、睡眠障碍、精神症状	-	肺癌	糖皮质激素、氯硝西泮	部分缓解
3	刘步珍^[20]（2005）	男性	63	眼阵挛、肌阵挛、共济失调	—	小细胞肺癌	原发肿瘤治疗	完全缓解
4	Jones和Chen^[21]（2022）	女性	27	恶心、头晕、步态不稳、眼阵挛、体位性震颤、动作性肌阵挛、宽基步态	-	卵巢癌	糖皮质激素、IVIg、利妥昔单抗	迅速缓解，随访30个月无复发
5	Miraclin等^[2]（2023）	女性	28	共济失调、全身震颤、肌阵挛、癫痫发作、精神行为异常，睡眠障碍	-	卵巢畸胎瘤	原发肿瘤治疗、糖皮质激素	完全缓解，随访2年所有日常生活活动均可独立完成
6	Kostoglou等^[18]（2021）	女性	43	癫痫发作、眼球运动障碍、共济失调、幻听、失眠	抗Ri抗体（+）	乳腺癌	血浆置换、糖皮质激素	部分缓解
7	Taib等^[22]（2015）	女性	50	头晕、精神错乱、步态不稳、眼阵挛、肌阵挛、小脑功能障碍	-	鼻咽癌	原发肿瘤治疗、糖皮质激素、IVIg	部分缓解
8	Blaes等^[23]（2003）	女性	58	斜视性眼阵挛、肌阵挛、共济失调	AMA（+）	小细胞肺癌	原发肿瘤治疗、糖皮质激素	遗留轻度共济失调
9	Rosenow等^[24]（2022）	女性	46	恶心、呕吐、眩晕、构音障碍、肌阵挛、眼阵挛、步态不稳	肌肉乙酰胆碱受体结合抗体（+），抗CASPR2抗体（+）	肺癌	原发肿瘤治疗、血浆置换、糖皮质激素、IVIg	死亡
10	Nwafor等^[12]（2019）	女性	72	眼阵挛、腹肌阵挛、共济失调	抗VGKC抗体（+）	胰腺癌	原发肿瘤治疗、糖皮质激素、劳拉西泮、左乙拉西坦	死亡
11	Sena等^[7]（2020）	女性	72	视物模糊、复视、步态障碍	抗Ri抗体（+）	乳腺癌	原发肿瘤治疗	部分缓解
12	Grubbs等^[25]（2016）	女性	53	眼阵挛、肌阵挛、抽搐、失衡、言语不清、认知功能减退	-	DLBCL	IVIg、糖皮质激素、甲氨蝶呤、长春新碱、利妥昔单抗	死亡
13	Stewart等^[26]（2019）	女性	54	肢体震颤、斜视性眼阵挛、面部和双上肢肌强直性抽搐	抗Ri抗体（+）	卵巢癌	原发肿瘤治疗、糖皮质素、氯硝西泮	神经系统症状完全缓解，随访10年未复发但肿瘤复发
14	Mahesh等^[27]（2019）	女性	14	斜视性眼阵挛、肌阵挛、共济失调	-	卵巢畸胎瘤	原发肿瘤治疗、IVIg、糖皮质激素	完全缓解
15	Martins等^[28]（2019）	女性	49	睡眠障碍、眼阵挛、肌阵挛、共济失调	抗Ri抗体（+）	乳腺癌	原发肿瘤治疗、他莫昔芬、糖皮质激素、利妥昔单抗、氯硝西泮、左乙拉西坦	6个月后抗Ri抗体转阴，未复发
16	Laroumagne等^[29]（2014）	男性	65	共济失调、肌阵挛、眼球震颤	抗GAD65抗体（+）	小细胞肺癌	原发肿瘤治疗、糖皮质激素	死亡
17	Musunuru等^[30]（2008）	女性	63	恶心、眩晕、构音障碍、步态不稳、斜视性眼阵挛、肌阵挛	抗Ri抗体（+）	非小细胞肺癌	原发肿瘤治疗、糖皮质激素	死亡
18	Moreira等^[31]（2022）	男性	69	眩晕、恶心、呕吐、构音障碍、眼球震颤、肌阵挛、共济失调	-	小细胞肺癌	原发肿瘤治疗、糖皮质激素	死亡
19	Reinecke等^[32]（2022）	女性	33	恶心、呕吐、头部震颤、构音障碍、肌阵挛、斜视性眼阵挛、共济失调	-	胰腺神经内分泌肿瘤	糖皮质激素、血浆置换	遗留共济失调
20	Soares等^[33]（2022）	女性	53	眩晕、恶心、呕吐、四肢抽搐、精运动不能、步态异常	-	乳腺癌	原发肿瘤治疗、糖皮质激素、利妥昔单抗	3个月后偶尔出现眩晕和轻微手部震颤
21	本文患者	女性	56	头晕、眼阵挛、肌阵挛、共济失调	抗Ri抗体（+）	无	IVIg、糖皮质激素	16个月后死于肺部感染

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Adult paraneoplastic opsoclonus-myoclonus-ataxia syndrome: one case report

成人副肿瘤性眼阵挛-肌阵挛-共济失调综合征一例

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Adult paraneoplastic opsoclonus-myoclonus-ataxia syndrome: one case report

成人副肿瘤性眼阵挛-肌阵挛-共济失调综合征一例

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