Clinical research progress of deep brain stimulation for Meige's syndrome

doi:10.3969/j.issn.1672-6731.2024.07.003

Abstract

Abstract:

Meige's syndrome (MS) is a segmental dystonia characterized by blepharospasm and oromandibular dystonia. Early treatment with medication or local injection of botulinum toxin can achieve certain therapeutic effects, but long-term use leads to decreased efficacy and adverse reactions, posing challenges to the treatment of the disease. Deep brain stimulation (DBS) has become a new treatment method for Meige's syndrome due to its safety, effectiveness, minimally invasive nature, reversibility, and controllability. This article reviews the clinical manifestations, pathogenesis of Meige's syndrome, as well as the mechanism and efficacy of DBS treatment, to improve clinical understanding of DBS treatment for Meige's syndrome.

Key words: Meige syndrome, Deep brain stimulation, Review

摘要：

Meige综合征是一种以眼睑痉挛和口-下颌肌张力障碍为主要特征的节段型肌张力障碍，早期药物治疗或局部注射肉毒毒素可取得一定疗效，但长期应用导致疗效下降和不良反应给治疗带来挑战。脑深部电刺激术因其安全、有效、微创、可逆、可调控等特征，成为一种新型Meige综合征治疗方法。本文对Meige综合征的临床表现和发病机制以及脑深部电刺激术治疗机制和疗效进展进行综述，以提高临床对脑深部电刺激术治疗Meige综合征的认识。

关键词: Meige综合征, 深部脑刺激法, 综述

Gui-zhi WU, Hong TIAN. Clinical research progress of deep brain stimulation for Meige's syndrome[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2024, 24(7): 516-521.

吴桂智, 田宏. Meige综合征脑深部电刺激术治疗进展[J]. 中国现代神经疾病杂志, 2024, 24(7): 516-521.

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