Chinese Journal of Contemporary Neurology and Neurosurgery ›› 2023, Vol. 23 ›› Issue (6): 566-570. doi: 10.3969/j.issn.1672-6731.2023.06.016

• Review • Previous Articles    

Advance on mechanism of type 2 diabetes mellitus increasing the risk of Parkinson's disease

Min WANG1, Jie QIN2, Lan-xin LI3, Xin LI2, Lei CHEN2,*()   

  1. 1. Grade 2020, Clinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical University, Tianjin 300070, China
    2. Department of Neurology, Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin Huanhu Hospital, Tianjin 300350, China
    3. Grade 2021, Clinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical University, Tianjin 300070, China
  • Received:2023-05-16 Online:2023-06-25 Published:2023-07-05
  • Contact: Lei CHEN
  • Supported by:
    Tianjin Medical Key Discipline (Specialty) Construction Project(TJYXZDXK-052B)

2型糖尿病增加帕金森病风险相关机制研究进展

王敏1, 秦洁2, 李岚昕3, 李欣2, 陈蕾2,*()   

  1. 1. 300070 天津医科大学神经内外科及神经康复临床学院2020级
    2. 300350 天津市环湖医院神经内科天津市脑血管与神经变性重点实验室
    3. 300070 天津医科大学神经内外科及神经康复临床学院2021级
  • 通讯作者: 陈蕾
  • 作者简介:

    王敏与秦洁对本文有同等贡献

    WANG Min and QIN Jie contributed equally to the article

  • 基金资助:
    天津市医学重点学科(专科)建设项目(TJYXZDXK-052B)

Abstract:

Parkinson's disease(PD), in which neurotoxicity caused by hyperglycemia and cerebral insulin resistance may play important roles, and the specific mechanism is not certain.Chronic hyperglycemia may lead to the injury of substantia nigra dopaminergic neuron by promoting oxidative stress, neuroinflammation, the formation of advanced glycation end products and endogenous neurotoxin.Moreover, insulin resistance may be involved in several pathways.This article mainly reviews the mechanism of T2DM increasing the risk of PD and provides guidance for the prevention and treatment of PD in patients with T2DM.

Key words: Parkinson's disease, Diabetes mellitus, type 2, Hyperglycemia, Insulin resistance, Review

摘要:

2型糖尿病与帕金森病的发生发展密切相关,其中高血糖导致的神经毒性和脑组织胰岛素抵抗发挥重要作用,但具体机制尚不明确。慢性血糖升高可能通过促进氧化应激、神经炎症、晚期糖基化终末产物和内源性神经毒素形成,导致黑质多巴胺能神经元损伤,而胰岛素抵抗通过多种途径参与其中。本文对2型糖尿病增加帕金森病风险的作用机制进行综述,为2型糖尿病患者的帕金森病预防与治疗提供指导。

关键词: 帕金森病, 糖尿病, 2型, 高血糖症, 胰岛素抵抗, 综述