Chinese Journal of Contemporary Neurology and Neurosurgery ›› 2023, Vol. 23 ›› Issue (2): 94-99. doi: 10.3969/j.issn.1672-6731.2023.02.004

• Epilepsy and Paroxysmal Disorder • Previous Articles     Next Articles

Progress of clinical research on autoimmune-associated epilepsy

REN Rui-qing, SHEN Kai-yuan, DING Jing, WANG Xin   

  1. Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
  • Received:2023-02-17 Online:2023-02-25 Published:2023-03-01
  • Supported by:
    This study was supported by Financial Support of National Key Research and Development Program of China (No. 2022YFC2503800).

自身免疫相关性癫痫临床研究进展

任瑞青, 沈恺源, 丁晶, 汪昕   

  1. 200032 上海, 复旦大学附属中山医院神经内科
  • 通讯作者: 丁晶,Email:ding.jing@zs-hospital.sh.cn;汪昕,Email:wang.xin@zs-hospital.sh.cn
  • 基金资助:
    国家重点研发计划重点专项(项目编号:2022YFC2503800)

Abstract: Etiology of epilepsy is complex. Immune has been defined as one of the etiological groups of epilepsy. Autoimmune epilepsy attracts experts worldwide to investigate and new conceptual definitions has been proposed. Based on the pathophysiology, autoimmune epilepsy includes two entities, which are acute symptomatic seizures secondary to autoimmune encephalitis (AE) and autoimmune-associated epilepsy (AAE). We interpret the new concepts, the characteristics of extracellular and intracellular neuronal antibodies which contribute to the pathogenesis of epilepsy, and AE manifested by seizures in this review. We hope that the article helps researchers and clinicians have a better understanding of AAE and use standard terms in practical situations, thus improving diagnosis and treatment of epilepsy.

Key words: Encephalitis, Autoimmune diseases, Epilepsy, Autoantibodies, Neurons, Review

摘要: 癫痫病因复杂,免疫因素已成为癫痫的独立病因。随着对“自身免疫性癫痫”概念和发病机制的深入研究,提出“继发于自身免疫性脑炎的急性症状性发作”和“自身免疫相关性癫痫”两个概念。本文介绍“自身免疫相关性癫痫”概念进展,阐述抗神经元细胞内或细胞表面抗原抗体通过不同途径介导癫痫发作的作用机制,总结常见的以癫痫发作为主要表现的自身免疫性脑炎,以提高临床对自身免疫相关性癫痫的认识及诊断术语的规范。

关键词: 脑炎, 自身免疫疾病, 癫痫, 自身抗体, 神经元, 综述