Chinese Journal of Contemporary Neurology and Neurosurgery ›› 2022, Vol. 22 ›› Issue (4): 217-223. doi: 10.3969/j.issn.1672-6731.2022.04.001

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Adaptive deep brain stimulation for motor disorders

MENG Fan-gang1,2, ZHANG Jian-guo1   

  1. 1 Department of Neurosurgery, Beijing Tiantan Hospital; Beijing Neurosurgical Institute; Beijing Key Laboratory of Neurostimulation, Capital Medical University, Beijing 100070, China;
    2 Chinese Institute for Brain Research, Beijing 102206, China
  • Received:2022-04-20 Online:2022-04-25 Published:2022-05-05
  • Supported by:
    This study was supported by the National Natural Science Foundation of China (No. 81971070), and Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support (No. XMLX201833).

自适应脑深部电刺激术治疗运动障碍性疾病研究进展

孟凡刚1,2, 张建国1   

  1. 1. 100070 首都医科大学附属北京天坛医院神经外科北京市神经外科研究所神经电刺激研究与治疗北京市重点实验室;
    2. 102206 北京脑科学与类脑研究中心
  • 通讯作者: 张建国, Email:zjguo73@126.com
  • 基金资助:
    国家自然科学基金资助项目(项目编号:81971070);北京市医院管理局临床医学发展专项(项目编号:XMLX201833)

Abstract: Deep brain stimulation (DBS) is one of the most effective treatment methods for movement disorders, but there are still limitations in efficacy and adverse reactions, which may be due to the existing stimulation mode is too fixed to adjust according to the individual situation of patients. Adaptive deep brain stimulation (aDBS) based on the level of brain electrophysiological activity can adjust the stimulation mode with the change of clinical symptoms, which is more effective. The preliminary study of aDBS confirms its effectiveness. This article describes the electrophysiological signals involved in aDBS and its application progress in movement disorders.

Key words: Movement disorders, Deep brain stimulation, Electrophysiology, Review

摘要: 脑深部电刺激术是运动障碍性疾病最有效的治疗方法之一,但在疗效和不良反应等方面仍存局限性,可能是由于现有的刺激模式过于固定,无法进行个体化调整。根据大脑电生理活动触发电刺激的自适应脑深部电刺激术可以随临床症状的变化而调整刺激模式,初步证实其疗效更佳。本文阐述自适应脑深部电刺激术的电生理学标志物及其在运动障碍性疾病中的应用进展。

关键词: 动作障碍, 深部脑刺激法, 电生理学, 综述