Chinese Journal of Contemporary Neurology and Neurosurgery ›› 2022, Vol. 22 ›› Issue (1): 31-37. doi: 10.3969/j.issn.1672-6731.2022.01.005

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Neuromyelitis optica spectrum disorders and pregnancy

LIU Qiang1, ZHANG Qing1, QUAN Chao2   

  1. 1. Department of Neurology, General Hospital of Ningxia Medical University, Yinchuan 750004, Ningxia, China;
    2. Department of Neurology, Huashan Hospital, Fudan University; National Center for Neurological Disorders, Shanghai 200040, China
  • Received:2021-12-24 Online:2022-01-25 Published:2022-01-22
  • Supported by:
    This study was supported by the National Natural Science Foundation of China (No. 81771296, 82171341)

视神经脊髓炎谱系疾病与妊娠

刘强1, 张庆1, 全超2   

  1. 1. 750004 银川,宁夏医科大学总医院神经内科;
    2. 200040 上海,复旦大学附属华山医院神经内科 国家神经疾病医学中心
  • 通讯作者: 全超,Email:chao_quan@fudan.edu.cn E-mail:chao_quan@fudan.edu.cn
  • 基金资助:
    国家自然科学基金资助项目(项目编号:81771296);国家自然科学基金资助项目(项目编号:82171341)

Abstract: Neuromyelitis optica spectrum diseases (NMOSDs) is an autoimmune disease of central nervous system, which occurs frequently in women of childbearing age. NMOSDs may affect pregnancy planning and fertility, and the effect on pregnancy outcome is not clear. Pregnancy can cause changes in the immune system and sex hormone levels, which results in NMOSDs recurrence and progression. Reasonable immunosuppressive treatment may effectively avoid pregnancy - related disease activities using low-dose corticosteroids, azathioprine and rituximab may be safe during pregnancy and after delivery.

Key words: Neuromyelitis optica, Pregnancy, Femininity, Review

摘要: 视神经脊髓炎谱系疾病是一种中枢神经系统自身免疫性疾病,好发于育龄期女性,可影响妊娠计划、生育能力,对妊娠结局的影响尚不明确;妊娠可引起免疫系统和性激素水平变化,造成疾病复发和进展。合理的免疫抑制治疗可以有效避免妊娠相关疾病活动。妊娠期和分娩后应用小剂量糖皮质激素、硫唑嘌呤和利妥昔单抗可能是安全的。

关键词: 视神经脊髓炎, 妊娠, 女性, 综述