Research progress of single-cell omics in central nervous system immune diseases

doi:10.3969/j.issn.1672-6731.2022.01.002

Abstract

Abstract: Central nervous system immune diseases include multiple sclerosis (MS), neuromyelitis optica spectrum disorders (NMOSDs), myelin oligodendrocyte glycoprotein - IgG associated disorders (MOGAD) and anti - N - methyl - D - aspartate receptor (NMDAR) encephalitis. The pathogenesis of these diseases is complex, and a variety of central nervous system and peripheral cells are involved. Single-cell omics has achieved high -resolution detection of the expression profile at the level of single -cell through a series of sequencing techniques to analyze cell heterogeneity and functional phenotype. This review will summarize the single cell sequencing (SCS) and its applications in the above-mentioned diseases.

Key words: Autoimmune diseases, Central nervous system diseases, Sequence analysis, B-lymphocytes, T-lymphocytes, Monocytes, Macrophages, Microglia, Dendritic cells, Review

摘要： 中枢神经系统免疫性疾病包括多发性硬化、视神经脊髓炎谱系疾病、抗髓鞘少突胶质细胞糖蛋白抗体相关疾病和抗N-甲基-D-天冬氨酸受体脑炎等，发病机制复杂，多种中枢神经系统和外周来源细胞参与其中。单细胞组学通过一系列测序技术实现高分辨检测单个细胞水平表达谱，以解析细胞异质性及其功能表型。本文对单细胞测序技术在常见中枢神经系统免疫性疾病各类型细胞研究中的进展进行综述。

关键词: 自身免疫疾病, 中枢神经系统疾病, 序列分析, B-淋巴细胞, T淋巴细胞, 单核细胞, 巨噬细胞, 小神经胶质细胞, 树突细胞, 综述

LI Zhi-bin, CHENG Xi, QIU Wei. Research progress of single-cell omics in central nervous system immune diseases[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2022, 22(1): 8-16.

李志彬, 程希, 邱伟. 中枢神经系统免疫性疾病单细胞组学研究进展[J]. 中国现代神经疾病杂志, 2022, 22(1): 8-16.

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http://journal11.magtechjournal.com/cjcnn/EN/Y2022/V22/I1/8

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