Progress in early diagnosis and management of sleep disorder in patients with Alzheimer's disease

doi:10.3969/j.issn.1672-6731.2021.12.004

Abstract

Abstract: Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive cognitive dysfunction and mental behavioral impairment. Sleep disorder is not only a common clinical symptom of AD, but also a risk factor for accelerating the pathological progression of the disease and cognitive impairment. As there is no effective intervention target for AD at present, sleep disorder is a controllable risk factor for AD, and early and correct diagnosis and management of sleep disorder play a key role in delaying the progression of AD. This article reviews the clinical manifestations, risk factors, early screening and management of sleep disorder in AD, in order to explore new therapeutic targets for AD from the perspective of sleep.

Key words: Alzheimer disease, Sleep disorders, Amyloid beta-peptides, Tau proteins, Review

摘要： 阿尔茨海默病是以进行性认知功能障碍和精神行为异常为特征的神经变性病。睡眠障碍既是阿尔茨海默病的常见临床症状，又是加速疾病进展和认知功能障碍的危险因素，二者存在交互作用。由于目前阿尔茨海默病尚无有效干预靶点，睡眠障碍作为其可控危险因素，早期准确诊断并管理睡眠障碍对延缓阿尔茨海默病进展具有重要作用。本文综述阿尔茨海默病睡眠障碍的临床表现、危险因素、早期筛查及管理，以期从睡眠角度探索阿尔茨海默病治疗的新靶点。

关键词: 阿尔茨海默病, 睡眠障碍, 淀粉样β肽类, tau蛋白质类, 综述

TANG Shi, DU Yi-feng. Progress in early diagnosis and management of sleep disorder in patients with Alzheimer's disease[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2021, 21(12): 1042-1045.

唐诗, 杜怡峰. 阿尔茨海默病患者睡眠障碍早期诊断与管理进展[J]. 中国现代神经疾病杂志, 2021, 21(12): 1042-1045.

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URL: http://journal11.magtechjournal.com/cjcnn/EN/10.3969/j.issn.1672-6731.2021.12.004

http://journal11.magtechjournal.com/cjcnn/EN/Y2021/V21/I12/1042

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