Chinese Journal of Contemporary Neurology and Neurosurgery ›› 2019, Vol. 19 ›› Issue (8): 567-572. doi: 10.3969/j.issn.1672-6731.2019.08.006

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The study of relationship between total burden of cerebral small vessel disease and plasma homocysteine

QIU Bao-shan, LAN Lin-fang, YANG Li-zhi, CAI Ying, LIAO Meng-shi, FAN Yu-hua   

  1. Department of Neurology, National Key Clinical Department and Key Discipline of Neurology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, Guangdong, China Department of Neurology, Jieyang People's Hospital, Jieyang 522000, Guangdong, China
  • Online:2019-08-25 Published:2019-08-27
  • Contact: FAN Yu-hua (Email: fansusan@126.com)
  • About author:Department of Neurology, National Key Clinical Department and Key Discipline of Neurology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, Guangdong, China Department of Neurology, Jieyang People's Hospital, Jieyang 522000, Guangdong, China
  • Supported by:

    This study was supported by National Key Research and Development Program of China (No. 2016YFC1300600), the Southern China International Cooperation Base for Early Intervention and Functional Rehabilitation of Neurological Diseases (No. 2015B050501003), Guangdong Provincial Key Laboratory for Diagnosisand Treatmentof MajorNeurologicalDiseases(No.2014B030301035), Guangdong Provincial Foundation for Major Neurological Disease Treatment, and Guangzhou Clinical Research, and Translational Center for Major Neurological Diseases (No.201604020010).

脑小血管病总体负荷与血浆同型半胱氨酸关系初探

邱宝山,蓝琳芳,杨丽芝,蔡颖,廖梦诗,范玉华   

  1. 510080 广州,中山大学附属第一医院神经科国家临床重点专科、重点学科(邱宝山,蓝琳芳,蔡颖,廖梦诗,范玉华);522000 广东省揭阳市人民医院神经内科(杨丽芝)
  • 通讯作者: 范玉华,Email:fansusan@126.com
  • 作者简介:510080 广州,中山大学附属第一医院神经科国家临床重点专科、重点学科(邱宝山,蓝琳芳,蔡颖,廖梦诗,范玉华);522000 广东省揭阳市人民医院神经内科(杨丽芝)
  • 基金资助:

    国家重点研发计划项目(项目编号:2016YFC1300600);华南神经疾病早期干预及功能修复研究国际合作基地基金资助项目(项目编号:2015B050501003);广东省重大神经疾病诊治研究重点实验室基金资助项目(项目编号: 2014B030301035);广东省神经系统重大疾病诊治基金资助项目;广东省广州市重大疾病临床医学研究与转化中心基金资助项目(项目编号:201604020010)

Abstract:

Objective To investigate preliminarily the relationship between the total burden of cerebral small vessel disease (cSVD) and plasma homocysteine (Hcy). Methods A total of 106 patients with cSVD were consecutively enrolled from January 2015 to October 2017. Plasma Hcy test were performed in all patients. The total burden of cSVD was calculated according to the severity of lacunar infarcts, white matter lesions, cerebral microbleeds and enlarged perivascular space according to MRI. Results Patients were divided into low burden group (96 cases) and high burden group (10 cases) based on total burden scores of cSVD. The level of Hcy in plasma of high burden group was seem to be higher than that in low burden group without significant difference (t = - 1.702, P = 0.090). Univariate and multivariate stepwise Logistic regression analysis showed that Hcy level of plasm (OR =1.041, 95%CI: 0.952-1.138, P=0.381) and Hyperhomocysteinemia (OR=3.132, 95%CI: 0.740-13.259; P=0.121) could not be proved to be risk factor of increasing cSVD burden. Conclusions Although plasma Hcy cannot be considered to be one of the risk factors for cSVD based on this study, plasma Hcy need to be further investigated as a potential biomarker for cSVD.

Key words: Cerebral small vessel diseases, Cysteine, Risk factors, Regression analysis

摘要:

目的 初步探讨脑小血管病总体负荷与血浆同型半胱氨酸之间的关系。方法 选择 2015年1月至2017年10月入院的106例脑小血管病患者为观察对象,测定血浆同型半胱氨酸水平,根据MRI检查获得的腔隙性梗死、脑白质高信号、脑微出血和扩大的血管周围间隙共4项影像学标志,评价脑小血管病总体负荷。结果 根据脑小血管病总体负荷评分情况分为低负荷组(96例)和高负荷组(10例),高负荷组血浆同型半胱氨酸水平有高于低负荷组之趋势但未达到统计学意义(t=-1.702, P= 0.090)。单因素和多因素逐步法Logistic回归分析未能证实血浆同型半胱氨酸水平(OR=1.041,95%CI: 0.952~1.138; P=0.381)和高同型半胱氨酸血症(OR=3.132,95%CI:0.740~13.259; P=0.121)是脑小血管病总体负荷增加的危险因素。结论 未得出血浆同型半胱氨酸水平和高同型半胱氨酸血症是脑小血管病总体负荷增加的危险因素的结论,但血浆同型半胱氨酸作为预测脑小血管病的可能标志物,值得深入研究。

关键词: 大脑小血管疾病, 半胱氨酸, 危险因素, 回归分析