Abstract:

Objective  To estimate the effect of lorazepam in relieving postoperative wound pain and anxiety after spinal meningioma surgery.  Methods  A total of 106 patients underwent spinal meningioma resection with endotracheal general anesthesia. They were randomly divided into lorazepam group (N = 53) and control group (N = 53). Patients in lorazepam group were given lorazepam 0.50 mg one night before surgery and 6 h after surgery, while control group were given compound vitamin B at the same time. Operation time, intraoperative bleeding and wound healing after surgery were recorded. McCormick grade and Self-Rating Anxiety Scale (SAS) were used to evaluate the spinal function and anxiety. At 48 h after surgery, Visual Analogue Scale (VAS) was used to evaluate the degree of postoperative pain.  Results  All patients underwent tumor total resection, and spent the perioperative period safely. No complications such as infection happened. Neurological function were relieved to varying degrees and there was no worsening case. Compared with control group, SAS score in lorazepam group was significantly decreased at 48 h after surgery (P = 0.000). Compared with before surgery, SAS score in lorazepam group was significantly decreased at 48 h after surgery (P = 0.000). The VAS score at 48 h after surgery in lorazepam group was significantly lower than control group [(5.40 ± 1.24) score vs. (7.15 ± 1.12) score; t = 7.593, P = 0.000].  Conclusions  Lorazepam as an antianxiety agent can effectively relieve postoperative pain after spinal meningioma resection.

Key words: Lorazepam, Meningeal neoplasms, Pain, postoperative, Anxiety

摘要：

目的 探讨劳拉西泮对行脊膜瘤切除术的患者术后伤口疼痛和焦虑情绪的缓解作用。方法 共106 例气管插管全身麻醉下行脊膜瘤切除术患者随机分为劳拉西泮组（53 例）和对照组（53 例），劳拉西泮组于手术前一晚和术后6 h 服用劳拉西泮0.50 mg、对照组于手术前一晚和术后6 h 服用复合维生素B，分别于术前和术后48 h 采用McCormick 神经功能分级和焦虑自评量表（SAS）评价脊髓功能和焦虑情绪，术后48 h 采用视觉模拟评分（VAS）评价术后伤口疼痛程度。结果两组患者均于手术显微镜下全切除肿瘤，并安全度过围手术期，无一例发生感染等手术相关并发症，术后神经功能均不同程度恢复，无神经功能损害加重患者。与对照组相比，劳拉西泮组患者术后48 h SAS 评分降低（P = 0.000）；与治疗前相比，术后48 h 劳拉西泮组患者SAS 评分降低（P = 0.000）。劳拉西泮组患者术后48 h VAS 评分低于对照组［（5.40 ± 1.24）分对（7.15 ± 1.12）分；t = 7.593，P = 0.000］。结论 脊膜瘤切除术患者术前和术后应用劳拉西泮抗焦虑治疗，可以有效缓解术后伤口疼痛。

关键词: 劳拉西泮, 脑膜肿瘤, 疼痛, 手术后, 焦虑