Abstract:

Small fiber neuropathy (SFN) is a kind of peripheral neuropathy in which the thinly myelinated A δ fibers and unmyelinated C fibers are predominantly affected, characterized by allodynia, analgesia, thermoanesthesia and/or autonomic nerve dysfunction. Nerve conduction velocity (NCV) detection can detect the pathological changes of large fibers (Aα and Aβ fibers) but not of small fibers, which lack of value in the diagnosis of SFN. Progress of the examinational and diagnostic methods for the neuropathological, neuroelectrophysiological and autonomic nerve functions of SFN in recent years were introduced in this paper.

Key words: Small fiber neuropathy, Diagnosis, Review

摘要：

小纤维神经病系指主要累及小直径有髓鞘Aδ类纤维和无髓鞘C 类纤维的一组疾病，典型表现为异常疼痛、痛温觉缺失和自主神经功能障碍。神经传导速度检测可以检出大纤维（Aα类和Aβ类纤维）病变，而无法评价小纤维功能。本文拟对近年来小纤维神经病的神经病理学、神经电生理学和自主神经功能检测等筛查和诊断方法研究进展进行简要概述。

关键词: 小纤维神经病, 诊断, 综述