Abstract:

Recent studies indicate that blood-brain barrier (BBB) breakdown may play an important role in the pathophysiology of cognitive dysfunction and dementia. BBB regulates the homeostasis of brain microenvironment, controls the transfer of required nutrients (e.g., glucose and amino acids), and limits entry of blood - derived products, pathogens and neurotoxins into the brain tissue. Recent advances in neuroimaging techniques offer new possibilities to realize positioning and quantitative detection of BBB disruption. It provides a new insertion point for elucidating the pathogenesis of Alzheimer's disease (AD).

Key words: Alzheimer disease, Blood-brain barrier, Magnetic resonance imaging, Review

摘要：

近年研究表明血-脑屏障功能障碍在认知功能障碍和痴呆的病理生理学机制中扮演重要角色。血-脑屏障可以调节脑微环境稳态，调控营养物质（如葡萄糖和氨基酸）转运，阻止血源性产物、病原体和神经毒性物质进入脑组织。神经影像学技术可以实现血-脑屏障完整性破坏的定位和定量分析，为阐明阿尔茨海默病发病机制提供新的切入点。

关键词: 阿尔茨海默病, 血脑屏障, 磁共振成像, 综述