Abstract:

Parkinson's disease (PD) is characterized by the progressive degeneration of dopaminergic neurons in substantia nigra pars compacta. Rehabilitation therapy can delay the development of disease, improve motor symptoms and non - motor symptoms (NMS), and consequently improve the activities of daily living (ADL) in patients with PD. The mechanism of rehabilitation improving the symptoms of PD is very complex, involving a variety of molecular mechanisms. Thus, this review will focus on the effect of rehabilitation therapy on PD and the underlying molecular mechanism including neurotransmitters, trophic factors, synaptic plasticity and immune system.

Key words: Parkinson disease, Rehabilitation, Review

摘要：

帕金森病是渐进性黑质致密部多巴胺能神经元退行性变导致的疾病，康复治疗可以延缓病情进展，改善运动症状和非运动症状，提高患者日常生活活动能力。康复训练改善帕金森病症状的机制复杂，涉及多种分子学机制，本文系统阐述康复训练对帕金森病症状的改善作用，以及神经递质、营养因子、突触可塑性和免疫系统等方面的分子学机制。

关键词: 帕金森病, 康复, 综述