Chinese Journal of Contemporary Neurology and Neurosurgery ›› 2016, Vol. 16 ›› Issue (12): 871-875. doi: 10.3969/j.issn.1672-6731.2016.12.011

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Research progress of relationship between gap junctions and movement disorders

WANG Hai-lei1, CHEN Xian-wen2, XIA Yuan-liang1   

  1. 1Department of Neurology, Fuyang Tumor Hospital of Anhui Province, Fuyang 236000, Anhui, China 2Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui, China
  • Online:2016-12-25 Published:2016-12-20
  • Contact: WANG Hai-lei (Email: 527336814@qq.com)
  • Supported by:

    This study was supported by Scientific and Technical Plan Project of Anhui Province, China(No. 10021303036)

缝隙连接与运动障碍性疾病研究进展

王海雷, 陈先文, 夏元亮   

  1. 236000 安徽省阜阳市肿瘤医院神经内科(王海雷,夏元亮);230022 合肥,安徽医科大学第一附属医院神经内科(陈先文)
  • 通讯作者: 王海雷(Email:527336814@qq.com)
  • 基金资助:

    安徽省科技计划项目(项目编号:10021303036)

Abstract:

Gap junctions (GJ) is an important way to transmit signals among body cells. Studies have confirmed that changes on structure and composition of gap junction proteins are associated with many kinds of diseases. Movement disorders is a common disease of the central nervous system (CNS), which has a certain degree of correlation with GJ, and it has become a key factor in the domestic and foreign research of pathogenesis and treatment mechanism of central nervons system diseases. This paper reviews GJ and its relationship with movement disorders.

Key words: Gap junctions, Connexins, Movement disorders,  Review

摘要:

缝隙连接是细胞间信号转导的重要方式。缝隙连接及其所组成的蛋白结构和(或)功能改变与多种疾病相关。运动障碍性疾病作为中枢神经系统的常见疾病,与缝隙连接有一定的关联性,其已成为国内外研究中枢神经系统疾病发病与治疗机制的关键因素。本文就缝隙连接及其与运动障碍性疾病的相关性进行概述。

关键词: 缝隙接合部, 连接蛋白类, 运动障碍, 综述