Abstract:

Forty-eight patients diagnosed as Guillain-Barré syndrome (GBS) in our hospital were retrospectively analyzed, including clinical manifestations, laboratory tests, neuroelectrophysiological tests, treatment and prognosis. In these patients, 81.25% (39/48) started with limb weakness or numbness, especially prominent for both lower limbs; 93.75% (45/48) had decreased or disappeared tendon reflex. Cerebrospinal fluid (CSF) tests showed albumin-cytological dissection in 38 patients. Neuroelectrophysiological tests in 42 patients revealed that the conduction velocity of F wave was decreased or was not elicited, the conduction velocity of motor and sensory nerves slowed down, and compound muscle action potential (CMAP) amplitude decreased. A total of 43 patients received intravenous immunoglobulin (IVIg), and 97.67% (42/43) showed improved muscle strength after treatment. A few patients showed atypical signs and symptoms for GBS, such as unilateral facial hypalgesia and positive pathological signs. Clinical manifestations, laboratory tests and neuroelectrophysiological tests should be combined to make early diagnosis and improve the prognosis.

Key words: Guillain-Barre syndrome, Cerebrospinal fluid, Electrophysiology

摘要：

回顾分析48 例吉兰-巴雷综合征患者的临床表现、实验室和神经电生理学特点、治疗及预后。临床以肢体无力、麻木为首发症状者占81.25%（39/48），尤以双下肢显著；四肢腱反射减弱或消失者占93.75%（45/48）。38 例患者脑脊液出现蛋白-细胞分离现象。42 例患者神经电生理学显示，F 波传导速度减慢或未引出、运动和感觉神经传导速度减慢、复合肌肉动作电位波幅下降。43 例患者静脉注射免疫球蛋白，97.67%（42/43）肌力较前好转。亦有少数患者出现不典型临床症状与体征，如单侧面部痛觉减退、病理征阳性等。临床医师应结合临床表现、实验室和神经电生理学检查等综合判断，早期明确诊断，改善患者预后。

关键词: 格林-巴利综合征, 脑脊髓液, 电生理学