Chinese Journal of Contemporary Neurology and Neurosurgery ›› 2016, Vol. 16 ›› Issue (5): 303-306. doi: 10.3969/j.issn.1672-6731.2016.05.011

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Microvascular changes and the mechanism in Alzheimer's disease

HU Xi-mei, YUAN Yu-jun, MA Ying   

  1. Department of Neurology, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning, China
  • Online:2016-05-25 Published:2016-05-24
  • Contact: MA Ying (Email: mayingwfd@163.com)
  • Supported by:

    This study was supported by the National Natural Science Foundation for Young Scholars of China (No. 81200834), Natural Science Foundation of Liaoning Province, China (No. 2013021070), and Shenyang Science and Technology Plan Program of Liaoning Province, China (No. F10-205-1-10).

阿尔茨海默病微血管改变及其机制

胡细枚, 袁裕钧, 马英   

  1. 110004 沈阳,中国医科大学附属盛京医院神经内科
  • 通讯作者: 马英(Email:mayingwfd@163.com)
  • 基金资助:

    国家自然科学基金青年科学基金资助项目(项目编号:81200834);辽宁省自然科学基金资助项目( 项目编号:2013021070);辽宁省沈阳市科技计划项目( 项目编号:F10-205-1-10)

Abstract:

Till now, the pathogenic mechanism of Alzheimer's disease (AD) is not completely clear. Extensive literatures have shown that the local cerebral microvascular disease occurs before neurodegeneration and cognitive impairment, and local blood flow reduction happens before the clinical symptoms of AD. This reveals that the microvascular changes are probably the important pathogenic manifestation in the AD formation and involved in the occurrence and development of AD. In this review, we explore the possible pathogenic mechanism of AD by analyzing the morphological changes of microvasculature, and the effects of vascular endothelial growth factor (VEGF), oxidative stress and amyloid β-protein (Aβ) on microvasculature respectively.

Key words: Alzheimer disease, Vascular endothelial growth factors, Oxidative stress, Amyloid, Review

摘要:

阿尔茨海默病发病机制至今尚未完全明确,但局部微血管改变发生于神经退行性变和认知功能障碍之前,且局部脑血流量降低先于临床症状的现象已经大量研究证实,提示脑微血管改变可能是阿尔茨海默病进展过程中的催化剂,参与其发生与发展。本文通过对阿尔茨海默病脑微血管结构,以及血管内皮生长因子、氧化应激反应、β-淀粉样蛋白对微血管影响相关研究进展的概述,以探讨阿尔茨海默病的可能发病机制。

关键词: 阿尔茨海默病, 血管内皮生长因子类, 氧化性应激, 淀粉样蛋白, 综述