Abstract:

Amyloid β (Aβ)-related central nervous system (CNS) vasculitis, which is also known as cerebral amyloid angiopathy (CAA)-related CNS vasculitis, is characterized by the presence of chronic inflammation within or around the walls of Aβ-deposit blood vessels. Cerebral biopsy is the gold standard for diagnosis of A β-related CNS vasculitis considering the atypical clinical features, cerebrospinal fluid (CSF) and neuroimaging findings of some patients. This paper reviewed the pathogenesis, neuropathology, clinical features, treatment and prognosis of Aβ-related CNS vasculitis

Key words: Amyloid beta-protein, Vasculitis, central nervous system, Pathology, Review

摘要：

淀粉样脑血管病相关性中枢神经系统血管炎亦称为β-淀粉样蛋白（Aβ）相关性中枢神经系统血管炎，主要表现为存在Aβ沉积的小血管壁或其周围慢性炎症性变。考虑部分患者临床表现、脑脊液和影像学表现不典型，明确诊断仍需依靠脑组织活检。本文拟就其发病机制、病理学特征、临床表现、治疗及预后等进展进行概述。

关键词: 淀粉样β蛋白, 血管炎, 中枢神经系统, 病理学, 综述