Chinese Journal of Contemporary Neurology and Neurosurgery ›› 2015, Vol. 15 ›› Issue (6): 437-441. doi: 10.3969/j.issn.1672-6731.2015.06.004

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Study on T2 mapping in thigh muscles of patients with Duchenne muscular dystrophy

LIANG Ying-yin1, CAO Ji-qing1, LING Jian2, LIN Er-jian2, LI Ming3, ZHANG Cheng1   

  1. 1Department of Neurology, 2Department of Radiology, 3Department of General Medicine, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, Guangdong, China
  • Online:2015-06-25 Published:2015-07-05
  • Contact: ZHANG Cheng (Email: zhangch6@mail.sysu.edu.cn)

Duchenne型肌营养不良症患儿大腿肌肉T2 mapping成像研究

梁颖茵, 操基清, 凌坚, 林尔坚, 李鸣, 张成   

  1. 510080 广州,中山大学附属第一医院神经科[梁颖茵、操基清(现在湖北省武汉市中心医院神经内科,邮政编码:430014)、张成],医学影像科(凌坚、林尔坚),内科(李鸣)
  • 通讯作者: 张成(Email:zhangch6@mail.sysu.edu.cn)

Abstract:

Objective  Use T2 mapping to evaluate the fatty infiltration of thigh muscles in Duchenne muscular dystrophy (DMD) patients, so as to analyze the value of T2 mapping and T2 relaxation time in the diagnosis of DMD.  Methods  Sixteen DMD patients who were admitted from January 2004 to January 2013 in our hospital and were diagnosed by clinical confirmation and gene detection have participated into this study. These 16 male patients formed the DMD group. Six age- and sex-matched healthy boys were selected as control group. Clinical functional scale, thigh axial T1WI-turbo spin echo (TSE), T2WI-TSE, spectral attenuated inversion recovery (SPAIR)-T2WI and T2 mapping were performed in both 2 groups. T1WI fatty infiltration scale and T2 relaxation time were assessed in adductor magnus, gracilis, adductor longus, sartorius, rectus femoris, vastus intermedius, vastus medialis, vastus lateralis, biceps femoris, semitendinosus and semimembranosus. Spearman rank correlation was conducted to assess the correlation between T2 relaxation time and T1WI fatty infiltration scale or clinical functional scale.  Results  Compared with control group, the T2 relaxation time of 8 muscles (adductor magnus, adductor longus, rectus femoris, vastus intermedius, vastus medialis, vastus lateralis, biceps femoris and semimembranosus) in DMD group were prolonged (P < 0.05, for all). The longest average T2 relaxation time was found in adductor magnus. The T2 relaxation time of adductor magnus, vastus intermedius, vastus lateralis, biceps femoris, rectus femoris, adductor longus and vastus medialis was positively correlated with T1WI fatty infiltration scale (P < 0.05, for all), and the T2 relaxation time of adductor magnus and semimembranosus was positively correlated with clinical funetional scale (P < 0.05, for all). A positive correlation was found in adductor magnus between T2 relaxation time and both T1WI fatty infiltration scale (rs = 0.867, P = 0.000) and clinical functional scale (rs = 0.651, P = 0.005).  Conclusions  T2 relaxation time could be used in the quantitative and objective analysis of DMD clinical severity, and adductor magnus was considered to be the most valuable muscle to reflect the clinical severity of DMD.

Key words:

摘要:

目的 采用T2 mapping 成像测定Duchenne 型肌营养不良症患儿大腿肌肉T2 弛豫时间,以评价T2 mapping 成像在Duchenne 型肌营养不良症诊断中的价值。方法 共16 例Duchenne 型肌营养不良症患儿,均行临床严重程度分级,常规MRI(横断面T1WI、T2WI、频谱衰减反转恢复序列-T2WI脂肪抑制像)行大腿肌肉T1WI脂肪浸润分级,T2 mapping 成像测定T2弛豫时间。Spearman 秩相关分析评价T2弛豫时间与T1WI脂肪浸润程度和临床严重程度的相关性。结果 与正常对照者相比,Duchenne 型肌营养不良症患儿大收肌、长收肌、股直肌、股中间肌、股内侧肌、股外侧肌、股二头肌和半膜肌共8 块肌肉T2 弛豫时间延长(均P < 0.05),其中大收肌、股中间肌、股外侧肌、股二头肌、股直肌、长收肌和股内侧肌T2 弛豫时间与T1WI 脂肪浸润程度呈正相关(均P < 0.05),大收肌和半膜肌T2 弛豫时间与临床严重程度呈正相关(均P < 0.05);T2 弛豫时间与T1WI 脂肪浸润程度和临床严重程度均呈正相关者仅大收肌(rs = 0.867,P = 0.000;rs = 0.651,P = 0.005)。结论 T2 弛豫时间测定可用于量化和客观分析Duchenne 型肌营养不良症的严重程度,大收肌是反映临床严重程度的最理想肌肉。

关键词: 肌营养不良, 杜氏, 腿, 磁共振成像