Abstract: Oxidative stress refers to the pathological process of cell oxidative damage that caused by increased reactive oxygen species (ROS) aggregation in vivo, due to the excessive generation of ROS and/or decreased anti-oxidant ability, resulting in imbalance between ROS producing and scavenging mechanism. Oxidative stress, which is closely related with cerebrovascular diseases, is involved in the pathological process of many diseases. Several cerebrovascular disease risk factors, such as smoking, blood glucose fluctuation, hyperlipemia, hypertension and hyperhomocysteinemia, can cause the increasing of ROS.

Key words: Stroke, Reactive oxygen species, Oxidative stress, Risk factors, Review

摘要： 氧化应激系指机体活性氧产生过多和（或）机体抗氧化能力减弱，产生与清除失衡，导致活性氧在体内聚积并引起细胞氧化损伤的病理过程。这一病理过程与脑血管病关系密切，吸烟、血糖水平波动、高脂血症、高血压和高同型半胱氨酸血症等多种脑血管病危险因素均可使活性氧的产生增加。

关键词: 卒中, 活性氧, 氧化性应激, 危险因素, 综述