Abstract: High-grade gliomas are central nervous system malignancies which are difficult to treat. Surgery, temozolomide combined with radiotherapy postoperatively and adjuvant chemotherapy with temozolomide have been established as the standard treatment options for high-grade gliomas. Nevertheless, the prognosis of patients with high-grade gliomas remains poor. At present, there is no standard therapy for recurrent or relapsed high-grade gliomas. Temozolomide is still an effective drug for the treatment of recurrent high-grade gliomas. According to the characteristics of patients, there have been many kinds of temozolomide administration and other treatments in combination. Individual therapy were paid more attention, so that the patients with high-grade gliomas recurrence could get greater survival benefit. This paper aims to introduce the progress of temozolomide in the treatment of recurrent high-grade gliomas in recent years.

Key words: Glioma, Neoplasm recurrence, local, Temozolomide (not in MeSH), Review

摘要： 高级别胶质瘤是一种难治性中枢神经系统恶性肿瘤，手术切除、术后替莫唑胺联合放射治疗及替莫唑胺辅助化疗是标准治疗方案。迄今为止，复发性高级别胶质瘤尚无标准治疗方案，替莫唑胺仍是其一线治疗药物，随着临床试验研究的不断深入，根据患者临床特点已出现多种替莫唑胺给药方式和联合治疗方案，更加注重个体化治疗使复发性高级别胶质瘤患者有更大的生存获益。本文拟就替莫唑胺治疗复发性高级别胶质瘤的进展予以介绍。

关键词: 神经胶质瘤, 肿瘤复发, 局部, 替莫唑胺（非MeSH 词）, 综述