Chinese Journal of Contemporary Neurology and Neurosurgery ›› 2013, Vol. 13 ›› Issue (5): 372-376. doi: 10.3969/j.issn.1672-6731.2013.05.004

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Neuropeptide S: a new neuropeptide that regulates sleep and wake

ZHAO Zheng-qing, LI Yan-peng, ZHAO Fei, ZHAO Zhong-xin   

  1. Department of Neurology, Changzheng Hospital, the Second Military Medical University of Chinese PLA, Shanghai 200003, China
  • Online:2013-05-25 Published:2013-06-06
  • Contact: ZHAO Zhong-xin (Email: zhaozx@medmail.com.cn)
  • Supported by:

    This study was supported by the National Natural Science Foundation of China (No. 81070070, 81100991, 81200061), "Twelfth Five-Year" Major Foundation by the Ministry of Science and Technology of China (No. 2011ZXJ09202-015) and Key Fund Project by Science and Technology Commission of Shanghai Municipality (No. 11411950203).

神经肽S:睡眠-觉醒相关新型神经肽

赵正卿, 李雁鹏, 赵菲, 赵忠新   

  1. 200003 上海,第二军医大学附属长征医院神经内科
  • 通讯作者: 赵忠新(Email:zhaozx@medmail.com.cn)
  • 基金资助:

    国家自然科学基金资助项目(项目编号:81070070);国家自然科学基金青年科学基金资助项目(项目编号:81100991);国家自然科学基金青年科学基金资助项目(项目编号:81200061);国家科技部“ 十二五”重大专项课题( 项目编号:2011ZXJ09202-015);上海市科委科研计划重点项目(项目编号:11411950203

Abstract: Neuropeptide S (NPS), a new peptide possessing 20 amino acid residues, is one of the most recent examples of a neurotransmitter identified by the orphan receptor strategy. NPS selectively binds and activates an orphan G-protein-coupled receptors (GPCRs), named NPS receptor (NPSR). NPS and NPSR mRNA are expressed in the brain regions, such as locus coeruleus (LC), lateral parabrachial nucleus (LPBN), dorsal medial nucleus of thalamus, hypothalamus and amygdaloid nucleus. NPS induces behavioral arousal and promotes wakefulness by suppressing all stages of sleep. Further studies about effect of the NPS system in sleep and wake might help to discover a potential target for pharmacological treatment of sleep disorders.

Key words: Neuropeptides, Receptors, neuropeptide, Sleep disorders, Review

摘要: 神经肽S 是近年新发现的一种神经肽,其神经元主要分布于蓝斑、外侧臂旁核,并在丘脑背内侧核、下丘脑和杏仁核也有分散表达。神经肽S 通过与其特异性受体神经肽S 受体相结合而发挥生理作用,调节睡眠-觉醒系统、促觉醒、改善认知功能、抗焦虑等。进一步研究神经肽S 在睡眠-觉醒调节中的作用,使其作为药物治疗的新靶点,可为睡眠障碍等疾病的治疗提供新的研究方向。

关键词: 神经肽类, 受体, 神经肽, 睡眠障碍, 综述