Chinese Journal of Contemporary Neurology and Neurosurgery ›› 2013, Vol. 13 ›› Issue (5): 368-371. doi: 10.3969/j.issn.1672-6731.2013.05.003

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Regulatory mechanism in sleep-wake cycle: from a receptor view

ZHANG Zhao-huan, LIU Zhen-yu, ZHANG Han-wen, ZHAO Zhong-xin   

  1. Department of Neurology, Changzheng Hospital, the Second Military Medical University of Chinese PLA, Shanghai 200003, China
  • Online:2013-05-25 Published:2013-06-06
  • Contact: ZHAO Zhong-xin (Email: zhaozx@medmail.com.cn)
  • Supported by:

    This study was supported by the National Natural Science Foundation of China (No. 81070070, 81171252), "Twelfth Five-Year" Major Foundation by the Ministry of Science and Technology of China (No. 2011ZXJ09202-015) and Key Fund Project by Science and Technology Commission of Shanghai
    Municipality (No. 11411950203).

从受体角度研究睡眠-觉醒调控机制

张照环, 刘振宇, 张瀚文, 赵忠新   

  1. 200003 上海,第二军医大学附属长征医院神经内科
  • 通讯作者: 赵忠新 (Email:zhaozx@medmail.com.cn)
  • 基金资助:

    国家自然科学基金资助项目(项目编号:81070070);国家自然科学基金资助项目(项目编号:81171252);国家科技部“十二五”重大专项课题(项目编号:2011ZXJ09202-015);上海市科委科研计划重点项目(项目编号:11411950203)

Abstract: Circadian rhythm is a universal phenomenon driven by the day-night cycle among the living beings on the earth. It is considered a basic element of life, which involves oscillations of most physiological activity through the body. The coordination of the different physiologic activities should be attributed to the convergence of a diversity of regulatory mechanisms. Among the multiple links in sleep-wake cycle, the receptors are of primary importance. Since they initiate the downstream signaling leading to cell responses, the receptors are considered a commonly intervention target. Here we summarize the major
receptors in sleep-wake regulation, along with a brief introduction of their functional findings, aiming to provide clues to further function understanding and intervention developing.

Key words: Sleep, Arousal, Circadian rhythm, Receptors, melatonin, Receptors, neuropeptide, Hormones, Receptors, neurotransmitter, Review

摘要: 生物日节律是地球生物受昼夜更替影响的普遍现象,是生命活动的基本组成,几乎涉及机体所有组织与器官的生理活动。这种全身协调的动态变化是多种机制的共同参与和信息整合。在所有参与睡眠-觉醒动态循环调控的环节中,受体至关重要,为细胞内信号效应的启动点,同时亦是重要的干预靶点。对目前已知参与睡眠-觉醒循环调节受体的种类进行归纳,并对其功能研究进展进行阐述,有助于进一步了解睡眠-觉醒的生理过程,亦为干预其病理生理变化的研究提供有效信息。

关键词: 睡眠, 觉醒, 昼夜节律, 受体, 褪黑激素, 受体, 神经肽, 激素类, 受体, 神经递质, 综述